MMP-3 Antibody (F-1): sc-271230

MMP-3 Antibody (F-1) is a mouse monoclonal IgG1 antibody that detects matrix metalloproteinase-3 (MMP-3) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MMP-3 plays a crucial role in the remodeling of the extracellular matrix by degrading various components, including collagen and proteoglycans, which is vital for processes such as tissue repair and development. Anti-MMP-3 antibody (F-1) activates procollagenase through both direct and indirect pathways, highlighting its importance in regulating collagen turnover, particularly in pathological conditions like cancer and inflammation. MMP-3 is expressed in various tissues, including the small intestine, lung, and heart, and its expression in stromal cells of breast carcinomas underscores its potential role in tumor progression and metastasis. MMP-3 (F-1) antibody serves as an essential tool for researchers investigating the dynamics of extracellular matrix remodeling and its implications in health and disease.

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MMP-3 Antibody (F-1) References:

1. Association between MMP-3 and MMP-9 polymorphisms and coronary artery disease.  |  Beton, O., et al. 2016. Biomed Rep. 5: 709-714. PMID: 28105338
2. Association of MMP-2, MMP-3, and MMP-9 Polymorphisms with Susceptibility to Recurrent Pregnancy Loss.  |  Behforouz, A., et al. 2021. Fetal Pediatr Pathol. 40: 378-386. PMID: 31955640
3. MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment.  |  Huth, S., et al. 2022. Lasers Med Sci. 37: 887-894. PMID: 33990899
4. Plasma Levels of Metalloproteinase 3 (MMP-3) and Metalloproteinase 7 (MMP-7) as New Candidates for Tumor Biomarkers in Diagnostic of Breast Cancer Patients.  |  Ławicki, P., et al. 2023. J Clin Med. 12: PMID: 37048701
5. Induction of MMP-3 and MMP-9 expression during Helicobacter pylori infection via MAPK signaling pathways.  |  Karayiannis, I., et al. 2023. Helicobacter. 28: e12987. PMID: 37139985
6. MMP-3 -1171 5A/6A promoter polymorphism and cancer susceptibility: an updated meta-analysis and trial sequential analysis.  |  Aziz, MA., et al. 2023. Future Oncol. 19: 1495-1512. PMID: 37551683
7. Chemokine Ligand 2 Promotes Migration in Osteosarcoma by Regulating the miR-3659/MMP-3 Axis.  |  Chang, YH., et al. 2023. Biomedicines. 11: PMID: 37893141
8. Clinical value of serum MMP-3 in chronic kidney disease.  |  Fu, Y., et al. 2024. Clin Chim Acta. 553: 117725. PMID: 38128817
9. Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes.  |  Jang, HY., et al. 2023. Int J Mol Sci. 24: PMID: 38139186
10. Diagnostic Utility of Selected Matrix Metalloproteinases (MMP-2, MMP-3, MMP-11, MMP-26), HE4, CA125 and ROMA Algorithm in Diagnosis of Ovarian Cancer.  |  Kicman, A., et al. 2024. Int J Mol Sci. 25: PMID: 38892452

The preferred MMP-3 antibody is MMP-3 Antibody (1B4): sc-21732.