Date published: 2025-9-7
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KIR6.2 Antibody (B-9) - Western Blotting - Image 369278
KIR6. 2 抗体 (B-9): sc-390104. KIR6. 2 在 HeLa (A), HL-60 (B), Hep G2 (C), MCF7 (D), MIA PaCa-2 (E) 和 3T3-L1 (F) 全细胞裂解液中表达的 Western 印迹分析. 所用检测试剂: m-IgGλ BP-HRP (Cruz Marker): sc-516132-CM.
KIR6. 2 抗体 (B-9): sc-390104. KIR6. 2 在 HeLa (A), HL-60 (B), Hep G2 (C), MCF7 (D), MIA PaCa-2 (E) 和 3T3-L1 (F) 全细胞裂解液中表达的 Western 印迹分析. 所用检测试剂: m-IgGλ BP-HRP (Cruz Marker): sc-516132-CM.

KIR6.2 抗体 (B-9): sc-390104

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寫評論提問

说明书
  • KIR6.2抗体(B-9)是小鼠单克隆IgG2a λ KIR6.2抗体, 在12篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的KIR6.2的内部区域内的氨基酸301-337之间
  • KIR6.2 抗体 (B-9) 推荐用于WB, IP, IF, IHC(P) 和 ELISA ，检测 mouse, rat, human 和 来源的KIR6.2; 也和以下物种反应，包括： 和 equine, canine, bovine and avian
  • 抗KIR6.2抗体（B-9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取KIR6.2 (B-9): sc-390104的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG2a BP-HRP 和 m-IgGλ BP-HRP 是 KIR6.2 抗体 (B-9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与KIR6.2 抗体 (B-9) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 KIR 抗体包括 KIR3.1, KIR3.4, KIR4.1, KIR4.2, KIR6.2 和 KIR7.1

KIR6.2抗体（B-9）是一种IgG2a λ小鼠单克隆KIR6.2抗体（也称为KCNJ11抗体或BIR抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的KIR6.2蛋白。KIR6.2抗体（B-9）可以以非偶联抗KIR6.2抗体的形式提供，也可以以多种偶联形式的抗KIR6.2抗体提供，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。ATP敏感性K+通道通过将细胞代谢与电活动相结合，在许多细胞功能中发挥重要作用。KIR6.1和KIR6.2是KIR（内向整流钾通道）家族钾通道的成员。内向整流K+通道具有更大的允许钾流入细胞而不是流出细胞的趋势。这些通道由两个亚基组成：一个KIR6.0亚家族成分和一个SUR成分，SUR是ATP结合盒蛋白超家族的成员。编码这些通道的基因突变是常染色体隐性遗传病的原因，其特征是胰岛素分泌不受调节。KIR通道亚基的氨基末端和羧基末端结构域均位于细胞内，KIR6.2的两个细胞内结构域在物理上相互作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

KIR6.2 抗体 (B-9) 参考文献:

  1. ATP 敏感钾通道：结构, 功能和病理生理学。  |  Inagaki, N. and Seino, S. 1998. Jpn J Physiol. 48: 397-412. PMID: 10021494
  2. ATP 敏感钾通道：异多聚体钾通道/受体组装模型。  |  Seino, S. 1999. Annu Rev Physiol. 61: 337-62. PMID: 10099692
  3. 分泌胰岛素的胰岛β细胞中对 ATP 敏感的 K+ 通道的结构和功能。  |  Miki, T., et al. 1999. J Mol Endocrinol. 22: 113-23. PMID: 10194514
  4. 先天性高胰岛素血症：一种异质性疾病的分子基础。  |  Meissner, T., et al. 1999. Hum Mutat. 13: 351-61. PMID: 10338089
  5. 绘制内向整流钾通道 Kir6.2 细胞内结构域之间的物理相互作用图。  |  Tucker, SJ. and Ashcroft, FM. 1999. J Biol Chem. 274: 33393-7. PMID: 10559219
  6. 模拟Kir6.2通道中PIP2诱导的开关转换。  |  Bründl, M., et al. 2021. Front Mol Biosci. 8: 711975. PMID: 34447786
  7. Kir6.2对通过调节PM20D1减少的线粒体ATP生成来维持神经元特征至关重要。  |  Song, N., et al. 2021. Redox Biol. 47: 102168. PMID: 34673451
  8. Kir6.2缺陷小鼠在外周神经中表现出躯体感觉功能障碍和轴突丢失。  |  Nakai-Shimoda, H., et al. 2022. iScience. 25: 103609. PMID: 35005553
  9. 开放型KATP通道的结构揭示了串联的PIP2结合位点，介导了Kir6.2和SUR1的调节界面。  |  Driggers, CM., et al. 2024. Nat Commun. 15: 2502. PMID: 38509107
  10. Kir6.2变体的分子动力学模拟揭示了与糖尿病的潜在关联。  |  Elangeeb, ME., et al. 2024. Molecules. 29: PMID: 38675722
  11. IKATP 的重组：内向整流亚基加磺酰脲受体。  |  Inagaki, N., et al. 1995. Science. 270: 1166-70. PMID: 7502040
  12. 内向整流钾通道：其分子异质性和功能。  |  Isomoto, S., et al. 1997. Jpn J Physiol. 47: 11-39. PMID: 9159640

订购信息

产品名称产品编号规格价格数量收藏夹

KIR6.2 抗体 (B-9)

sc-390104
200 µg/ml
$316.00

KIR6.2 (B-9): m-IgGλ BP-HRP 套装

sc-523404
200 µg Ab, 40 µg BP
$354.00

KIR6.2 (B-9): m-IgG2a BP-HRP 套装

sc-546237
200 µg Ab; 10 µg BP
$354.00

KIR6.2 抗体 (B-9) AC

sc-390104 AC
500 µg/ml, 25% agarose
$416.00

KIR6.2 抗体 (B-9) HRP

sc-390104 HRP
200 µg/ml
$316.00

KIR6.2 抗体 (B-9) FITC

sc-390104 FITC
200 µg/ml
$330.00

KIR6.2 抗体 (B-9) PE

sc-390104 PE
200 µg/ml
$343.00

KIR6.2 抗体 (B-9) Alexa Fluor® 488

sc-390104 AF488
200 µg/ml
$357.00

KIR6.2 抗体 (B-9) Alexa Fluor® 546

sc-390104 AF546
200 µg/ml
$357.00

KIR6.2 抗体 (B-9) Alexa Fluor® 594

sc-390104 AF594
200 µg/ml
$357.00

KIR6.2 抗体 (B-9) Alexa Fluor® 647

sc-390104 AF647
200 µg/ml
$357.00

KIR6.2 抗体 (B-9) Alexa Fluor® 680

sc-390104 AF680
200 µg/ml
$357.00

KIR6.2 抗体 (B-9) Alexa Fluor® 790

sc-390104 AF790
200 µg/ml
$357.00

KIR6.2 (B-9) 中和勝肽

sc-390104 P
100 µg/0.5 ml
$68.00

What is the scendary antibody? Rabit anti-mouse IgG? or Goat anti-mouse IgG? I can wait your answer. Thanks

Asked by: dkfma1143
Thank you for your question. You can use any anti-mouse secondary antibody with this mouse monoclonal primary antibody. Please contact our Technical Service Department by phone, e-mail or live chat if you have any further questions. Alternatively, you can contact your local distributor: https://www.scbt.com/scbt/resources/distributors
Answered by: Tech Service
Date published: 2017-06-26

Can the peptide sc-390104 P be used in Western Blot as a positive control?

Asked by: AbPolly
Thank you for your question. The blocking peptide sc-390104 P is a short synthetic peptide intended for use as a negative control by preadsorption. It is not appropriate for use as a positive control in Western Blot.
Answered by: Technical Support 3
Date published: 2017-02-09
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Rated 5 out of 5 by from Good resultsKir6.2(B-9)antibody Works good for western blot for both human and mouse atrial tissues lysate, dilution1:500, clean background and strong signal.
Date published: 2019-07-10
Rated 5 out of 5 by from Great for western blottingI've used this antibody at 1:200 dilution on mouse pancreatic islets with great results (clean specific band with no background).
Date published: 2018-02-13
Rated 5 out of 5 by from Good workingThis antibody is used for WB.The antibody incubated at RT for 1hour.No background but strong band at 50kda.I use the Hepg2 cell and loading 50ug sample.
Date published: 2017-08-12
Rated 5 out of 5 by from good resultWe get pretty results in WB assay, with a specific band. Our samples are mouse cell , the working dilution is 1: 300.
Date published: 2017-05-27
Rated 5 out of 5 by from 申请了10ug的试用装上个月申请了10ug的试用装，很好用，能做出sh-SY5Y细胞的全细胞蛋白。分子量在40-55marker的中间。
Date published: 2017-05-08
Rated 5 out of 5 by from It will provide specific detection.This antibody is supported by great staining and blotting data. It works well in typical lab applications and is reactive with a wide range of species.
Date published: 2017-01-27
Rated 5 out of 5 by from Produced positive Western blot data of KIR6Produced positive Western blot data of KIR6.2 expression in Sol8 and MIA PaCa-2 whole cell lysates and mouse brain tissue extract . -SCBT QC
Date published: 2014-04-13
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KIR6.2 抗体 (B-9) is rated 5.0 out of 5 by 7.
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