Date published: 2026-10-19
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IRF-4 Antibody (F-4) - Western Blotting - Image 398865
IRF-4 抗体 (F-4): sc-48338. Ramos (A) 和 GA-10 (B) 核提取物以及 NCI-H929 (C) 和 RPMI-8226 (D) 全细胞裂解液中 IRF-4 表达的 Western 印迹分析. 所用检测试剂: m-IgG Fc BP-HRP: sc-525409.
IRF-4 抗体 (F-4): sc-48338. Ramos (A) 和 GA-10 (B) 核提取物以及 NCI-H929 (C) 和 RPMI-8226 (D) 全细胞裂解液中 IRF-4 表达的 Western 印迹分析. 所用检测试剂: m-IgG Fc BP-HRP: sc-525409.

IRF-4 抗体 (F-4): sc-48338

4.4(10)
寫評論提問
说明书
  • IRF-4 抗体 F-4 是小鼠单克隆 IgG2a κ，IRF-4抗体, 在16篇文献中引用，规格为200 µg/ml
  • 免疫human物种的IRF-4的氨基酸128-267
  • IRF-4 抗体 (F-4) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 IRF-4
  • 抗IRF-4抗体（F-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 可用于凝胶迁移和ChIP的TransCruz试剂(sc-48338 X, 200 µg/0.1 ml)
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是IRF-4 Antibody (F-4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与IRF-4 Antibody (F-4) 打包提供（请参阅下面的订购信息）。
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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

额外IRF抗体，包括IRF-1, IRF-2, IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, IRF-2BP1和IRF-2BP

IRF-4抗体（F-4）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的IRF-4蛋白。IRF-4 (F-4) 抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。干扰素调节因子-4（IRF-4）在免疫系统中起着至关重要的作用，它是一种转录激活因子，可调节免疫反应相关基因的表达，尤其是淋巴细胞中的基因表达。IRF-4对于T辅助细胞2的分化以及浆细胞（抗体产生的关键）的发育至关重要。IRF-4能够与主要组织相容性复合物（MHC）I类启动子的干扰素刺激反应元件（ISRE）结合，这凸显了IRF-4在调节免疫反应和维持免疫平衡方面的重要性。此外，IRF-4与其他蛋白质（如PU.1）相互作用，这进一步凸显了IRF-4在调节免疫系统基因表达方面的作用。IRF-4在免疫调节中的多方面参与使其成为免疫学及相关领域的重要研究对象。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IRF-4 抗体 (F-4) 参考文献:

  1. IRF-4在B和T细胞活化和分化中的作用。  |  Pernis, AB. 2002. J Interferon Cytokine Res. 22: 111-20. PMID: 11846982
  2. IRF-4在转录调控中的作用。  |  Marecki, S. and Fenton, MJ. 2002. J Interferon Cytokine Res. 22: 121-33. PMID: 11846983
  3. IRF-4在HTLV-I诱导的T细胞白血病发生中的作用。  |  Mamane, Y., et al. 2002. J Interferon Cytokine Res. 22: 135-43. PMID: 11846984
  4. IRF-4在早期B细胞发育中起肿瘤抑制剂的作用。  |  Acquaviva, J., et al. 2008. Blood. 112: 3798-806. PMID: 18713947
  5. IRF-4和IRF-8缺陷之间的协同作用促进髓样和淋巴样肿瘤的发生。  |  Jo, SH., et al. 2010. Blood. 116: 2759-67. PMID: 20585039
  6. 干扰素调节因子 4（IRF-4）靶向 IRF-5，以调节 Epstein-Barr 病毒的转化。  |  Xu, D., et al. 2011. J Biol Chem. 286: 18261-7. PMID: 21454650
  7. IRF-4以一种与DNA结合无关的方式抑制髓系细胞的BCR/ABL转化。  |  Jo, SH. and Ren, R. 2012. J Biol Chem. 287: 1770-8. PMID: 22110133
  8. 犬皮肤组织细胞瘤中多发性骨髓瘤癌基因1/干扰素调节因子4（MUM1/IRF-4）的免疫组织化学标记。  |  Stilwell, JM. and Rissi, DR. 2018. Vet Pathol. 55: 517-520. PMID: 29444632
  9. 急性T细胞介导的排斥反应与稳定肾移植受者之间的IRF-4基因表达比较。  |  Freidoon, M., et al. 2021. Iran J Kidney Dis. 15: 222-228. PMID: 33994382
  10. IRF-4缺乏可减轻叶酸诱导的急性肾损伤后的炎症和肾脏纤维化。  |  Chen, M., et al. 2021. Int Immunopharmacol. 100: 108142. PMID: 34555644

订购信息

产品名称产品编号规格价格数量收藏夹

IRF-4 抗体 (F-4)

sc-48338
200 µg/ml
$322.00

IRF-4 (F-4): m-IgG Fc BP-HRP 套装

sc-525558
200 µg Ab; 10 µg BP
$361.00

IRF-4 (F-4): m-IgG2a BP-HRP 套装

sc-546314
200 µg Ab; 10 µg BP
$361.00

IRF-4 抗体 (F-4) X

sc-48338 X
200 µg/0.1 ml
$322.00

IRF-4 抗体 (F-4) AC

sc-48338 AC
500 µg/ml, 25% agarose
$424.00

IRF-4 抗体 (F-4) HRP

sc-48338 HRP
200 µg/ml
$322.00

IRF-4 抗体 (F-4) FITC

sc-48338 FITC
200 µg/ml
$336.00

IRF-4 抗体 (F-4) PE

sc-48338 PE
200 µg/ml
$349.00

IRF-4 抗体 (F-4) Alexa Fluor® 488

sc-48338 AF488
200 µg/ml
$364.00

IRF-4 抗体 (F-4) Alexa Fluor® 546

sc-48338 AF546
200 µg/ml
$364.00

IRF-4 抗体 (F-4) Alexa Fluor® 594

sc-48338 AF594
200 µg/ml
$364.00

IRF-4 抗体 (F-4) Alexa Fluor® 647

sc-48338 AF647
200 µg/ml
$364.00

IRF-4 抗体 (F-4) Alexa Fluor® 680

sc-48338 AF680
200 µg/ml
$364.00

IRF-4 抗体 (F-4) Alexa Fluor® 790

sc-48338 AF790
200 µg/ml
$364.00

Hi, I am interested in purchasing IRF4 antibody (Human/ mouse) that binds N terminus of the protein, and I was wondering whether you have mapped the epitope for IRF4 F-4 (sc-48338) or do you have any product that you could recommend?

Asked by: Bahareh
Thank you for your question. Anti-IRF-4 Antibody (F-4): sc-48338 was raised against amino acids 128-267 of IRF-4 of human origin.
Answered by: Tech Support Europe
Date published: 2021-06-25

Can the TransCruz Reagent sc-48338 X be used in applications other than ChIP and EMSA?

Asked by: AbPolly
Thank you for your question. Yes, the X form of the antibody can be used in other applications such as Western Blot, IF and IHC. The dilution factor needs to be adjusted as the X form is ten times as concentrated as the standard antibody.
Answered by: Technical Service
Date published: 2017-01-27
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Rated 5 out of 5 by imim from FACS stainingWe detected it by intracellular FACS staining in THP-1 cells.
Date published: 2024-05-14
Rated 1 out of 5 by NShaun from Zero starI bought this antibody twice, neither worked for IB, IP or IF. SC used to have goat IRF4 (M17) and mouse IRF4(MUM1p), both great for IP and IB. But they were discontinued and replaced with this garbage for no reason. It has been more and more antibodies from SC do not work, and you just waste your time and efforts to try them. So I am now switching to other companies.
Date published: 2019-09-18
Rated 5 out of 5 by diguadw23 from Great feature!The results of this antibody is really good and I really love it
Date published: 2018-01-05
Rated 3 out of 5 by Tsen from Good antibodyWorked well with western blotting at 1:500 dilution.
Date published: 2017-09-27
Rated 5 out of 5 by 1988_163 from greatThis antibody works really well in IF at 1:50 dilution.
Date published: 2017-08-23
Rated 5 out of 5 by Meng Jie from Used it in WBWe tested the Western blot, got a strong signal.good
Date published: 2017-04-05
Rated 5 out of 5 by daniell from it works for mouse liver proteinThe antibody worked well to detect the protein in mouse liver tissue by western blotting.
Date published: 2017-03-28
Rated 5 out of 5 by Germaine from Excellent choice ab for detecting IRF-4 in WBGives clear distinct bands in NAMALWA and GA-10 whole cell lysate
Date published: 2016-12-29
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IRF-4 抗体 (F-4) is rated 4.4 out of 5 by 10.
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