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IFN-α/βRα Antibody (H-11) - Immunofluorescence - Image 145955
IFN-a/bRa (H-11): sc-7391. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.
IFN-a/bRa (H-11): sc-7391. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示膜定位.

IFN-α/βRα 抗体 (H-11): sc-7391

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寫評論提問

说明书
  • IFN- alpha / beta R alpha 抗体 H-11 是小鼠单克隆 IgG1 κ，IFN-α/βRα抗体, 在33篇文献中引用，规格为200 µg/ml
  • 针对与human起源的IFN-α/βRα的C-terminus（完整的细胞内结构域）对应的氨基酸458-557
  • IFN- alpha / beta R alpha 抗体 (H-11) 推荐用于 WB, IP 和 IF，检测mouse, rat 和human 来源的 IFN-α/βR α chain
  • 抗IFN- alpha / beta R alpha抗体（H-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是IFN-α/βRα Antibody (H-11) for WB applications. 的首选辅助检测试剂，这些试剂现与IFN-α/βRα Antibody (H-11) 打包提供（请参阅下面的订购信息）。

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研究信息

関連項目

额外Interferon Receptor抗体，包括IFN-alpha / β R alpha, IFN-alpha / β R β, IFN-α R1, IFN-γ R α和IFN-γ R β

IFN-α/βRα抗体（H-11）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和免疫荧光（IF）检测小鼠、大鼠和人类来源的IFN-α/βRα蛋白。IFN-α/βRα 单克隆抗体（H-11）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。I型干扰素受体（包括IFN-α/βRα）通过调节I型干扰素的作用在免疫反应中发挥关键作用，而I型干扰素对于在细胞中建立抗病毒状态至关重要。IFN-α/βRα主要位于细胞表面，与干扰素α和β结合，触发一系列细胞内信号传导，激活参与抗病毒防御的基因。这个位置的重要性怎么强调都不为过，因为IFN-α/βRα能够对病毒感染做出快速反应，使细胞能够进行有效的防御。此外，IFN-α/βRα与细胞质酪氨酸激酶JAK1的相互作用对于信号转导至关重要，进一步强调了细胞定位在调节免疫反应中的重要性。了解IFN-α/βRα和信号通路的动态变化对于制定针对病毒感染和相关疾病的治疗策略至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IFN-α/βRα 抗体 (H-11) 参考文献:

  1. 用IFN-α、-β或-γ治疗会导致局灶性节段性肾小球硬化症。  |  Markowitz, GS., et al. 2010. Clin J Am Soc Nephrol. 5: 607-15. PMID: 20203164
  2. IFN-α在黑色素瘤治疗中的应用。  |  Tarhini, AA., et al. 2012. J Immunol. 189: 3789-93. PMID: 23042723
  3. 人类干扰素-γ 受体。抗体的纯化, 表征和制备。  |  Novick, D., et al. 1987. J Biol Chem. 262: 8483-7. PMID: 2954953
  4. 人类干扰素-γ 受体的分子克隆和表达。  |  Aguet, M., et al. 1988. Cell. 55: 273-80. PMID: 2971451
  5. IFN-α在COVID-19患者中的潜在作用及其潜在治疗方案。  |  Yang, L., et al. 2021. Appl Microbiol Biotechnol. 105: 4005-4015. PMID: 33950278
  6. STAM和Hrs依次与IFN-α受体相互作用，控制时空JAK-STAT内体激活。  |  Zanin, N., et al. 2023. Nat Cell Biol. 25: 425-438. PMID: 36797476
  7. IFN-α在类风湿性关节炎中的作用。  |  Lin, CMA., et al. 2024. Curr Rheumatol Rep. 26: 37-52. PMID: 38051494
  8. I 型和 II 型干扰素受体。  |  Orchansky, P., et al. 1984. J Interferon Res. 4: 275-82. PMID: 6086780
  9. 有证据表明 I 型和 II 型干扰素具有不同的受体。  |  Branca, AA. and Baglioni, C. 1981. Nature. 294: 768-70. PMID: 6172715
  10. 鉴定激活人类干扰素γ受体所需的辅助因子及其序列。  |  Soh, J., et al. 1994. Cell. 76: 793-802. PMID: 8124716
  11. 干扰素受体家族的一个新成员补充了鼠干扰素γ受体在人体细胞中的功能。  |  Hemmi, S., et al. 1994. Cell. 76: 803-10. PMID: 8124717
  12. 人类干扰素α/β受体：特征描述和分子克隆。  |  Novick, D., et al. 1994. Cell. 77: 391-400. PMID: 8181059

订购信息

产品名称产品编号规格价格数量收藏夹

IFN-α/βRα 抗体 (H-11)

sc-7391
200 µg/ml
$316.00

IFN-α/βRα (H-11): m-IgG Fc BP-HRP 套装

sc-526500
200 µg Ab; 10 µg BP
$354.00

IFN-α/βRα (H-11): m-IgG1 BP-HRP 套装

sc-531873
200 µg Ab; 20 µg BP
$354.00

IFN-α/βRα 抗体 (H-11) AC

sc-7391 AC
500 µg/ml, 25% agarose
$416.00

IFN-α/βRα 抗体 (H-11) HRP

sc-7391 HRP
200 µg/ml
$316.00

IFN-α/βRα 抗体 (H-11) FITC

sc-7391 FITC
200 µg/ml
$330.00

IFN-α/βRα 抗体 (H-11) PE

sc-7391 PE
200 µg/ml
$343.00

IFN-α/βRα 抗体 (H-11) Alexa Fluor® 488

sc-7391 AF488
200 µg/ml
$357.00

IFN-α/βRα 抗体 (H-11) Alexa Fluor® 546

sc-7391 AF546
200 µg/ml
$357.00

IFN-α/βRα 抗体 (H-11) Alexa Fluor® 594

sc-7391 AF594
200 µg/ml
$357.00

IFN-α/βRα 抗体 (H-11) Alexa Fluor® 647

sc-7391 AF647
200 µg/ml
$357.00

IFN-α/βRα 抗体 (H-11) Alexa Fluor® 680

sc-7391 AF680
200 µg/ml
$357.00

IFN-α/βRα 抗体 (H-11) Alexa Fluor® 790

sc-7391 AF790
200 µg/ml
$357.00

What is the total volume provided of IFN-α/βRα (H-11):sc-7391 monoclonal antibody?

Asked by: jenni
Thank you for your question. This antibody is provided as 200 µg in 1 ml total volume of PBS with < 0.1% sodium azide and 0.1% gelatin.
Answered by: Technical Support 4
Date published: 2017-01-13

What is the recommended fixation method for IF with IFN-α/βRα (H-11): sc-7391 monoclonal antibody?

Asked by: jenni
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10ºC methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support 4
Date published: 2017-01-13
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Rated 4 out of 5 by from Good antibodyThis anibody worked for WB with mouse tissue lysate.
Date published: 2020-02-05
Rated 4 out of 5 by from Good antibodyThis antibody worked very well with fixed frozen mouse tissue sections for IF
Date published: 2018-10-03
Rated 5 out of 5 by from Outstanding western and IFVery nice IF staining data; also strong western blot results
Date published: 2017-01-23
Rated 5 out of 5 by from Great staining resultsThis antibody shows good staining results in IF for human.
Date published: 2017-01-14
Rated 4 out of 5 by from This has worked well in WB&IF&IPThis has worked well in WB&IF&IP.
Date published: 2015-10-23
Rated 4 out of 5 by from This antibody works well and can be usedThis antibody works well and can be used for IP with human umbilical vein ECs. -SCBT Publication Review
Date published: 2015-06-10
Rated 5 out of 5 by from Good WB publishable data gathered with mouse HEKGood WB publishable data gathered with mouse HEK-293 cells. -SCBT Publication Review
Date published: 2015-04-11
Rated 5 out of 5 by from Publishable data in coimmunoprecipitationPublishable data in coimmunoprecipitation and Western blotting with this antibody -SCBT Publication Review
Date published: 2015-04-08
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IFN-α/βRα 抗体 (H-11) is rated 4.6 out of 5 by 12.
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