Anti-IFN-α/βRα Antibody (H-11) is a mouse monoclonal IgG1 (kappa light chain) IFN-α/βRα antibody provided at 200 µg/ml
raised against amino acids 458-557 mapping at the C-terminus (complete intracellular domain) of IFN-α/βRα of human origin
Anti-IFN- alpha / beta R alpha Antibody (H-11) is recommended for detection of IFN-α/βR α chain of mouse, rat and human origin by WB, IP and IF
Anti-IFN- alpha / beta R alpha Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of IFN-α/βRα (H-11): sc-7391.
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IFN-α/βRα Antibody (H-11) is a high quality monoclonal IFN- alpha / beta R alpha antibody (also designated IFN-α/βRα antibody) suitable for the detection of the IFN- alpha / beta R alpha protein of mouse, rat and human origin. IFN-α/βRα Antibody (H-11) is available as both the non-conjugated anti-IFN- alpha / beta R alpha antibody form, as well as multiple conjugated forms of anti-IFN- alpha / beta R alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The type I interferons (IFNs), α and β, are a group of structurally and functionally related proteins that are induced by either viruses or double stranded RNA and defined by their ability to confer an antiviral state in cells. The α and β IFNs appear to compete with one another for binding to a common cell surface receptor while immune IFN (IFNγ) binds to a distinct receptor. The latter protein, IFN-αR, is only weakly responsive to type I interferons in contrast to IFN-α/βR, which binds to and responds effectively to IFN-β and to several of the IFN-α subtypes. Moreover, IFN-α/βR is physically associated with the cytoplasmic tyrosine kinase JAK1 and thus, in addition to ligand binding, appears to be functionally involved in signal transduction. The IFN-γ receptor complex consists of an alpha subunit (IFN-γRα) and a beta subunit that is 332 amino acids in length (mouse) and 337 amino acids in length (human).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
What is the total volume provided of IFN-α/βRα (H-11):sc-7391 monoclonal antibody?
Asked by: jenni
Thank you for your question. This antibody is provided as 200 µg in 1 ml total volume of PBS with < 0.1% sodium azide and 0.1% gelatin.
Answered by: Technical Support 4
Date published: 2017-01-13
What is the recommended fixation method for IF with IFN-α/βRα (H-11): sc-7391 monoclonal antibody?
Asked by: jenni
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10ºC methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
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