Date published: 2025-9-7

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GSK3 alpha/beta 抗体 (1H8): sc-56913

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说明书
  • GSK3 alpha/beta抗体(1H8)是小鼠单克隆IgG2a κ, 在21篇文献中引用,规格为200 µg/ml
  • 免疫Xenopus laevis物种的重组GSK-3α/β
  • 推荐用于 mouse, rat, human 和 Xenopus laevis 来源的GSK-3α and GSK-3β WB 和 IP检测
  • 看 GSK3 alpha/beta (0011-A): sc-7291,可查看有标记的 GSK3 alpha/beta 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRPm-IgGκ BP-HRP是GSK3 alpha/beta Antibody (1H8) 适用于 WB 应用。 的首选辅助检测试剂,这些试剂现与GSK3 alpha/beta Antibody (1H8) 打包提供(请参阅下面的订购信息)。

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GSK-3α/β 抗体 (1H8) 是一种小鼠单克隆 IgG2a 抗体,可通过免疫印迹 (WB) 和免疫沉淀 (IP) 检测小鼠、大鼠、人和爪蟾中的糖原合酶激酶 3 (GSK-3)。GSK-3 是一种丝氨酸/苏氨酸、脯氨酸定向激酶,在各种信号通路(包括参与糖原合成和细胞粘附的信号通路)中发挥关键作用,并与阿尔茨海默病的发病机制有关。值得注意的是,GSK-3 有两种异构体,即 GSK-3α 和 GSK-3β,它们在亚细胞定位和功能作用上各不相同。GSK-3 主要位于细胞质中,但可以转位到细胞核中,在细胞核中 GSK-3 影响基因表达和细胞反应。这种定位使 GSK-3 能够调节各种细胞过程,包括细胞周期调节和细胞凋亡,从而影响细胞的整体健康和功能。GSK-3 活性失调与包括神经退行性疾病在内的多种疾病有关,这使得 GSK-3 成为治疗干预的关键靶点。GSK-3 还能使微管结合蛋白 Tau 磷酸化,导致 Tau 过度磷酸化和成对螺旋丝的形成,这是阿尔茨海默病病理特征之一。抗 GSK-3α/β 抗体 (1H8) 是研究人员调查 GSK-3 在健康和疾病中的复杂作用的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

订购信息

产品名称产品编号规格价格数量收藏夹

GSK3 alpha/beta 抗体 (1H8)

sc-56913
200 µg/ml
$316.00

GSK3 alpha/beta (1H8): m-IgG Fc BP-HRP 套装

sc-537127
200 µg Ab; 10 µg BP
$354.00

GSK3 alpha/beta (1H8): m-IgGκ BP-HRP 套装

sc-534319
200 µg Ab; 40 µg BP
$354.00

Does this antibody recognize the GSK3a/b fragments? Such as 30kd, and 15kd?

Asked by: Lanmio
Thank you for your question. We have not observed any fragments at 15 kDa using this antibody. Please refer to the representative Western blot data on our website.
Answered by: Technical Support
Date published: 2019-01-26

Are there any issues with using sc-56913: GSK-3α/β (1H8) mouse monoclonal primary antibody on mouse samples?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-56913 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 4 out of 5 by from Good antibodyFor endogenous GSK3 in B-cell lymphoma cells, the signaling is quite strong!
Date published: 2018-02-26
Rated 4 out of 5 by from LargeLarge, strong band in WB in A6 whole cell lysate. -SCBT QC
Date published: 2015-03-10
Rated 4 out of 5 by from Published data for WB in mouse brain samplePublished data for WB in mouse brain sample. -SCBT Publication Review
Date published: 2015-02-02
Rated 4 out of 5 by from Publishable data for WBPublishable data for WB, IP and IHC (P) in HeLa, HTC116 and Cos7 cell lines. -SCBT Publication Review
Date published: 2015-01-17
Rated 4 out of 5 by from Published data for WB in mouse skeletal musclePublished data for WB in mouse skeletal muscle sample. -SCBT Publication Review
Date published: 2015-01-07
Rated 4 out of 5 by from Published data for WB in human U2OS cellsPublished data for WB in human U2OS cells.
Date published: 2015-01-04
Rated 4 out of 5 by from Robust positive band seen in WB in CakiRobust positive band seen in WB in Caki-1, HeLa, A549, SK-BR-3, Jurkat and LNCaP whole cell lysates. -SCBT QC
Date published: 2013-07-19
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GSK3 alpha/beta 抗体 (1H8) is rated 4.0 out of 5 by 7.
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