GMD Antibody (C-7): sc-515226
- GMD Antibody (C-7) is a mouse monoclonal IgG1 κ GMD antibody provided at 200 µg/ml
- raised against amino acids 61-359 mapping within an internal region of GMD of human origin
- GMD Antibody (C-7) is recommended for detection of GMD of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GMD Antibody (C-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GMD Antibody (C-7) for WB applications. These reagents are now offered in bundles with GMD Antibody (C-7) (see ordering information below).
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GMD Antibody (C-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects GMD protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GMD (C-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GMD, also known as GDP-D-mannose dehydratase or GMDS, is a crucial enzyme consisting of 372 amino acids that plays a significant role in carbohydrate metabolism by catalyzing the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, utilizing NADP as a cofactor. This enzymatic activity is vital for the biosynthesis of glycoproteins and glycolipids, which are essential for cell signaling and structural integrity. Mutations in GMD have been implicated in resistance to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis, highlighting GMD′s importance in cancer biology. GMD is located on human chromosome 6, a region associated with various genetic disorders and cancer susceptibility, including early onset intestinal cancer and conditions such as Porphyria cutanea tarda and Parkinson′s disease. Understanding GMD′s function and implications is crucial for advancing research in metabolic pathways and therapeutic interventions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GMD Antibody (C-7) References:
- The FX enzyme is a functional component of lymphocyte activation. | Eshel, R., et al. 2001. Cell Immunol. 213: 141-8. PMID: 11831876
- Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22. | Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
- Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling. | Moriwaki, K., et al. 2009. Gastroenterology. 137: 188-98, 198.e1-2. PMID: 19361506
- FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. | Aldinger, KA., et al. 2009. Nat Genet. 41: 1037-42. PMID: 19668217
- Associations among behavior-related susceptibility factors in porphyria cutanea tarda. | Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
- A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene. | Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911
- Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. | Sullivan, FX., et al. 1998. J Biol Chem. 273: 8193-202. PMID: 9525924
- Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells. | Ohyama, C., et al. 1998. J Biol Chem. 273: 14582-7. PMID: 9603974
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GMD Antibody (C-7) | sc-515226 | 200 µg/ml | $322.00 | |||
GMD Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-531318 | 200 µg Ab; 10 µg BP | $361.00 | |||
GMD Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-524980 | 200 µg Ab, 40 µg BP | $361.00 | |||
GMD Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-544482 | 200 µg Ab; 20 µg BP | $361.00 | |||
GMD Antibody (C-7) AC | sc-515226 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GMD Antibody (C-7) HRP | sc-515226 HRP | 200 µg/ml | $322.00 | |||
GMD Antibody (C-7) FITC | sc-515226 FITC | 200 µg/ml | $336.00 | |||
GMD Antibody (C-7) PE | sc-515226 PE | 200 µg/ml | $349.00 | |||
GMD Antibody (C-7) Alexa Fluor® 488 | sc-515226 AF488 | 200 µg/ml | $364.00 | |||
GMD Antibody (C-7) Alexa Fluor® 546 | sc-515226 AF546 | 200 µg/ml | $364.00 | |||
GMD Antibody (C-7) Alexa Fluor® 594 | sc-515226 AF594 | 200 µg/ml | $364.00 | |||
GMD Antibody (C-7) Alexa Fluor® 647 | sc-515226 AF647 | 200 µg/ml | $364.00 | |||
GMD Antibody (C-7) Alexa Fluor® 680 | sc-515226 AF680 | 200 µg/ml | $364.00 | |||
GMD Antibody (C-7) Alexa Fluor® 790 | sc-515226 AF790 | 200 µg/ml | $364.00 |