Date published: 2025-9-8

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frizzled-3 抗体 (C-1): sc-376105

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说明书
  • frizzled-3 抗体 C-1 是小鼠单克隆 IgG2a κ,frizzled-3抗体, 在4篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列501-666位于human物种的frizzled-3的C-terminus
  • frizzled-3 抗体 (C-1) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 frizzled-3; 也和以下物种反应,包括: 和 equine and bovine
  • 抗frizzled-3抗体(C-1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取frizzled-3 (C-1): sc-376105免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2a BP-HRP">m-IgG2a BP-HRP是frizzled-3 Antibody (C-1) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与frizzled-3 Antibody (C-1) 打包提供(请参阅下面的订购信息)。

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関連項目

frizzled-3抗体(C-1)是一种IgG2a κ小鼠单克隆frizzled-3抗体(也称为FZD3抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人源frizzled-3蛋白。frizzled-3抗体(C-1)有非偶联抗frizzled-3抗体形式和多种偶联形式的抗frizzled-3抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。frizzled基因最初在果蝇中鉴定,参与组织极性的发育。已描述了frizzled的哺乳动物同源物以及几种分泌的哺乳动物frizzled相关蛋白(FRPs)。frizzled蛋白含有七个跨膜结构域,一个胞外区富含半胱氨酸的结构域和一个羧基末端Ser/Thr-xxx-Val基序。它们作为Wnt的受体起作用,通常与G蛋白偶联。FRPs通过调节β-catenin的细胞内水平参与Wnt信号通路。frizzled-3(Fz-3)是一种广泛表达的666个氨基酸的蛋白质,在中枢神经系统中表达相对较高。frizzled-3与精神分裂症有关,已被证明在神经嵴形成和毛囊发育中发挥作用。由于选择性剪接事件,存在两种已知的frizzled-3同工型。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

frizzled-3 抗体 (C-1) 参考文献:

  1. 染色体 8p21 上人类 frizzled-3 的分子克隆和基因组结构。  |  Kirikoshi, H., et al. 2000. Biochem Biophys Res Commun. 271: 8-14. PMID: 10777673
  2. 人类 Frizzled-3 (FZD3) 的鉴定, 基因结构和表达。  |  Sala, CF., et al. 2000. Biochem Biophys Res Commun. 273: 27-34. PMID: 10873558
  3. Kermit是一种褐飞虱互作蛋白,在神经嵴发育过程中调节褐飞虱3的信号传导。  |  Tan, C., et al. 2001. Development. 128: 3665-74. PMID: 11585793
  4. 中枢神经系统喙部主要纤维束的发育需要Frizzled-3。  |  Wang, Y., et al. 2002. J Neurosci. 22: 8563-73. PMID: 12351730
  5. 染色体 8p21 上的人类 frizzled-3 (FZD3)基因是 Wnt 配体的受体基因,与精神分裂症的易感性缔合作用。  |  Katsu, T., et al. 2003. Neurosci Lett. 353: 53-6. PMID: 14642436
  6. 人类Frizzled同源物3基因(FZD3)与精神分裂症之间的遗传关联调查:韩国人群的结果和荟萃分析的证据。  |  Jeong, SH., et al. 2006. Psychiatry Res. 143: 1-11. PMID: 16707163
  7. 人类肝细胞癌中 Wnt/Frizzled 受体元件的共同失调。  |  Bengochea, A., et al. 2008. Br J Cancer. 99: 143-50. PMID: 18577996
  8. 在日本人群中,Frizzled 3基因与甲基苯丙胺精神病有关。  |  Kishimoto, M., et al. 2008. Behav Brain Funct. 4: 37. PMID: 18702828

订购信息

产品名称产品编号规格价格数量收藏夹

frizzled-3 抗体 (C-1)

sc-376105
200 µg/ml
$316.00

frizzled-3 (C-1): m-IgG2a BP-HRP 套装

sc-545946
200 µg Ab; 10 µg BP
$354.00

frizzled-3 抗体 (C-1) AC

sc-376105 AC
500 µg/ml, 25% agarose
$416.00

frizzled-3 抗体 (C-1) HRP

sc-376105 HRP
200 µg/ml
$316.00

frizzled-3 抗体 (C-1) FITC

sc-376105 FITC
200 µg/ml
$330.00

frizzled-3 抗体 (C-1) PE

sc-376105 PE
200 µg/ml
$343.00

frizzled-3 抗体 (C-1) Alexa Fluor® 488

sc-376105 AF488
200 µg/ml
$357.00

frizzled-3 抗体 (C-1) Alexa Fluor® 546

sc-376105 AF546
200 µg/ml
$357.00

frizzled-3 抗体 (C-1) Alexa Fluor® 594

sc-376105 AF594
200 µg/ml
$357.00

frizzled-3 抗体 (C-1) Alexa Fluor® 647

sc-376105 AF647
200 µg/ml
$357.00

frizzled-3 抗体 (C-1) Alexa Fluor® 680

sc-376105 AF680
200 µg/ml
$357.00

frizzled-3 抗体 (C-1) Alexa Fluor® 790

sc-376105 AF790
200 µg/ml
$357.00

Hi, frizzled-3 Antibody (C-1): sc-376105 is unconjugated right? May I know which secondary antibody is suitable to be used with frizzled-3 Antibody (C-1): sc-376105 ?

Asked by: ryia
Thank you for your question. Yes, the standard antibody, frizzled-3 Antibody (C-1): sc-376105, is unconjugated. Directly conjugated forms of this primary antibody are also available. This is a mouse monoclonal IgG2a (kappa light chain). We would recommend using our mouse IgG kappa binding protein (m-IgGκ BP) conjugated to Horseradish Peroxidase (HRP), m-IgGκ BP-HRP: sc-516102 , for Western blotting. If you plan to use the antibody in a different application, please contact us and we can recommend the appropriate type of conjugated secondary antibody.
Answered by: Technical Support
Date published: 2019-01-26

Are there any issues with using sc-376105: frizzled-3 (C-1) mouse monoclonal primary antibody on mouse samples?

Asked by: TinTin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-376105 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 5 out of 5 by from Produced nice Western blot data of frizzledProduced nice Western blot data of frizzled-3 expression in Y79 whole cell lysate. -SCBT QC
Date published: 2014-02-19
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frizzled-3 抗体 (C-1) is rated 5.0 out of 5 by 1.
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