Date published: 2025-9-6
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Fascin 1 Antibody (D-10) - Western Blotting - Image 380910
Fascin 1 抗体 (D-10): sc-46675. 在 SH-SY5Y (A), IMR-32 (B), H4 (C), Neuro-2A (D) 和 EOC 20 (E) 全细胞裂解液及大鼠脑组织提取物 (F) 中 Fascin 1 表达的 Western 印迹分析.
Fascin 1 抗体 (D-10): sc-46675. 在 SH-SY5Y (A), IMR-32 (B), H4 (C), Neuro-2A (D) 和 EOC 20 (E) 全细胞裂解液及大鼠脑组织提取物 (F) 中 Fascin 1 表达的 Western 印迹分析.

Fascin 1 抗体 (D-10): sc-46675

5.0(10)
寫評論提問

说明书
  • Fascin 1 抗体 D-10 是小鼠单克隆 IgG1 κ，Fascin 1抗体, 在24篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Fascin 1的氨基酸384-493
  • Fascin 1 抗体 (D-10) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Fascin 1
  • 抗Fascin 1抗体（D-10）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Fascin 1 (D-10): sc-46675的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 Fascin 1 抗体 (D-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Fascin 1 抗体 (D-10) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 Fascin 抗体 包括 Fascin 2

Fascin 1 抗体（D-10）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的Fascin 1蛋白。Fascin 1 (D-10) 抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。Fascin 1在组织肌动蛋白细胞骨架方面发挥着至关重要的作用，特别是在形成肌动蛋白微刺方面，而肌动蛋白微刺对于细胞粘附和迁移至关重要。这些微刺的形成与细胞外基质成分（如血栓素1）有关，对于组织重塑和伤口愈合等过程至关重要。Fascin能够将肌动蛋白丝束捆绑在动态细胞结构中，包括微刺、应力纤维和膜皱褶，这凸显了其在维持细胞结构和促进运动中的重要性。Fascin 1已被确定为卵巢上皮异常病理的潜在预后标志物，也是卵巢癌治疗的新治疗靶点。Fascin是血液和组织中树突状细胞的重要识别标志，凸显了其在免疫反应中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Fascin 1 抗体 (D-10) 参考文献:

  1. 作为三阴性乳腺癌新型诊断标志物的 Fascin-1。  |  Wang, CQ., et al. 2016. Cancer Med. 5: 1983-8. PMID: 27184764
  2. 研究筋膜蛋白-1 在机械受压荚膜细胞中的作用  |  Kliewe, F., et al. 2017. Sci Rep. 7: 9916. PMID: 28855604
  3. Fascin-1通过促进大鼠脊髓炎症而引起神经性疼痛。  |  Wang, B., et al. 2018. Neurochem Res. 43: 287-296. PMID: 29052088
  4. 脊髓损伤后，Fascin-1 在小胶质细胞中特异性高表达并调控小胶质细胞迁移  |  Yu, S., et al. 2021. Front Pharmacol. 12: 729524. PMID: 34646136
  5. STAT3/HIF-1α/fascin-1轴在缺氧条件下促进RA FLS的迁移和侵袭能力。  |  Yang, W., et al. 2022. Mol Immunol. 142: 83-94. PMID: 34971867
  6. 肌动蛋白结合蛋白Fascin-1调节纤毛信号。  |  Brücker, L., et al. 2023. J Mol Cell Biol. 15: PMID: 37015875
  7. Fascin-1在乳腺癌的发病机制、转移和化疗耐药性中起关键作用。  |  Abdullah, AR., et al. 2024. Pathol Res Pract. 254: 155079. PMID: 38219494
  8. 一种抑制Fascin-1肌动蛋白结合活性和丝状突起形成的纳米抗体。  |  Burgess, SG., et al. 2024. Open Biol. 14: 230376. PMID: 38503329
  9. Fascin-1在肝癌中的表达及其诊断价值。  |  Lu, SP., et al. 2024. Sci Rep. 14: 10049. PMID: 38698008
  10. Fascin-1通过犬乳腺肿瘤细胞系中的上皮-间质转化促进细胞转移。  |  Wang, X., et al. 2024. Vet Sci. 11: PMID: 38921985

订购信息

产品名称产品编号规格价格数量收藏夹

Fascin 1 抗体 (D-10)

sc-46675
200 µg/ml
$316.00

Fascin 1 (D-10): m-IgG Fc BP-HRP 套装

sc-526720
200 µg Ab; 10 µg BP
$354.00

Fascin 1 (D-10): m-IgG1 BP-HRP 套装

sc-532093
200 µg Ab; 20 µg BP
$354.00

Fascin 1 抗体 (D-10) AC

sc-46675 AC
500 µg/ml, 25% agarose
$416.00

Fascin 1 抗体 (D-10) HRP

sc-46675 HRP
200 µg/ml
$316.00

Fascin 1 抗体 (D-10) FITC

sc-46675 FITC
200 µg/ml
$330.00

Fascin 1 抗体 (D-10) PE

sc-46675 PE
200 µg/ml
$343.00

Fascin 1 抗体 (D-10) Alexa Fluor® 488

sc-46675 AF488
200 µg/ml
$357.00

Fascin 1 抗体 (D-10) Alexa Fluor® 546

sc-46675 AF546
200 µg/ml
$357.00

Fascin 1 抗体 (D-10) Alexa Fluor® 594

sc-46675 AF594
200 µg/ml
$357.00

Fascin 1 抗体 (D-10) Alexa Fluor® 647

sc-46675 AF647
200 µg/ml
$357.00

Fascin 1 抗体 (D-10) Alexa Fluor® 680

sc-46675 AF680
200 µg/ml
$357.00

Fascin 1 抗体 (D-10) Alexa Fluor® 790

sc-46675 AF790
200 µg/ml
$357.00

Can Fascin 1 (D-10): sc-46675 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: AbPolly
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, Fascin 1 (D-10): sc-46675 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Good for western blotThis product works well in our western blot, shows clear bands with very good quality!
Date published: 2023-11-22
Rated 5 out of 5 by from Immunostaining results are excellentThe Fascin1 antibody purchased around October of last year was utilized for immunostaining a total of 360 colorectal cancer specimens. This resulted in a highly pronounced differentiation and excellent data outcomes. The accompanying images depict staining levels ranging from Grade 0 to Grade 3.
Date published: 2023-08-08
Rated 5 out of 5 by from Great antibody for western blotThe batch of antibody I have worked well on HeLa, MCF7, NIH/3T3 total cell extracts for western Blot. The band is specific. The antibody was diluted 1'000 times into 5% BSA,TBST and incubated over-night at 4°C.
Date published: 2018-01-04
Rated 5 out of 5 by from Great antibody for WB!This antibody works well in western blot. It gives a strong band at 55 kDa in human whole cell extracts
Date published: 2017-10-20
Rated 5 out of 5 by from Excellent for IF and WBExtremely strong affinity to Fascin. I detected Fascin at 1:2000 WB and and 1:250 IF. Very strong bands in WB.
Date published: 2017-09-22
Rated 5 out of 5 by from Excellent!This antibody works great in western blot analysis of Fascin 1 expression in PANC-1, MES-SA/Dx5, SH-SY5Y, Hep G2 and U-251-MG whole cell lysates.
Date published: 2017-02-02
Rated 5 out of 5 by from Successfully immunoprecipitated Fascin 1Successfully immunoprecipitated Fascin 1 from endothelials cells from bovine aorta, NIH-3T3 mouse fibroblastes and monkey CO57 cells; verified pull down with western blot analysis. -SCBT Publication Review
Date published: 2015-03-21
Rated 5 out of 5 by from CrispCrisp, clean bands in western blot analysis of Fascin expression in HeLa, NIH/3T3 and KNRK whole cell lysates. -SCBT QC
Date published: 2015-02-20
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Fascin 1 抗体 (D-10) is rated 5.0 out of 5 by 10.
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