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Dvl-3/Dishevelled 3/DVL3 抗体 (C-3): sc-365581

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说明书
  • Dvl-3/Dishevelled 3/DVL3抗体(C-3)是小鼠单克隆IgM κ, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的Dvl-3的N-terminus附近的氨基酸73-101之间
  • 推荐用于 mouse, rat 和 human 来源的Dvl-3 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 (): ,可查看有标记的 Dvl-3/Dishevelled 3/DVL3 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成Dvl-3/Dishevelled 3/DVL3 抗体 (C-3)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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已经鉴定出果蝇dishevelled(Dsh)基因的哺乳动物同源物,包括Dvl-1、Dvl-2和Dvl-3。哺乳动物dishevelled蛋白包含三个同源域,其中两个与其他任何已知蛋白无关。第三个区域与果蝇discs-large-1的discs-large同源域同源,这是一种肿瘤抑制蛋白。与它们的果蝇对应物一样,dishevelled蛋白被认为参与胚胎发育。已经显示Dvl-1的过表达抑制tau由GSK-3b磷酸化。这一发现可能在阿尔茨海默氏症的研究中证明是重要的,该研究表明tau是过度磷酸化的。在果蝇中,Dsh是frizzled信号通路的一个组成部分。哺乳动物的dishevelled和frizzled蛋白都是Wnt信号通路的组成部分。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Dvl-3/Dishevelled 3/DVL3 抗体 (C-3) 参考文献:

  1. Dvl和axin的DIX结构域对于蛋白质相互作用及其调节β-catenin稳定性的能力是必需的。  |  Kishida, S., et al. 1999. Mol Cell Biol. 19: 4414-22. PMID: 10330181
  2. 多巴胺D2受体通过Dvl-3调节Akt和GSK-3  |  Sutton, LP. and Rushlow, WJ. 2012. Int J Neuropsychopharmacol. 15: 965-79. PMID: 21777508
  3. Dishevelled-3通过p38依赖性途径激活p65上调p120-catenin转录,在非小细胞肺癌中。  |  Zhao, H., et al. 2015. Mol Carcinog. 54 Suppl 1: E112-21. PMID: 25156800
  4. 体外靶向dishevelled-3和表皮生长因子受体-酪氨酸激酶抑制剂对间皮瘤细胞的协同作用。  |  Moriyama, G., et al. 2018. Oncol Lett. 15: 833-838. PMID: 29403559
  5. Omega-3多不饱和脂肪酸通过抑制Wnt/β-catenin途径抑制肝癌的恶性进展。  |  Chang, FZ., et al. 2018. Eur Rev Med Pharmacol Sci. 22: 4500-4508. PMID: 30058686
  6. ASPM通过增强Wnt-Dvl-3-β-catenin信号促进前列腺癌的干性和进展。  |  Pai, VC., et al. 2019. Oncogene. 38: 1340-1353. PMID: 30266990
  7. 长期服用抗精神病药对大鼠腹侧中脑 PKA 和 GSK3β 介导的通路及 NMDA 受体的调节作用  |  Pan, B. and Deng, C. 2019. Psychopharmacology (Berl). 236: 2687-2697. PMID: 31053935
  8. 果蝇散乱极性基因的两个人类同源物的 cDNA 表征和染色体图谱。  |  Pizzuti, A., et al. 1996. Hum Mol Genet. 5: 953-8. PMID: 8817329
  9. 克隆人类DVL-3基因的cDNA,并将其定位到3q27,以及在人类乳腺癌和结肠癌中的表达。  |  Bui, TD., et al. 1997. Biochem Biophys Res Commun. 239: 510-6. PMID: 9344861

订购信息

产品名称产品编号规格价格数量收藏夹

Dvl-3/Dishevelled 3/DVL3 抗体 (C-3)

sc-365581
200 µg/ml
$322.00

Dvl-3/Dishevelled 3/DVL3 (C-3) 中和勝肽

sc-365581 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-365581 P appropriate for?

Asked by: cjMara
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by LR from Works well for western blotting using transfectedWorks well for western blotting using transfected 293 whole cell lysates. -SCBT QC
Date published: 2015-04-24
Rated 5 out of 5 by HF from Produced superb immunoperoxidase cytoplasmicProduced superb immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human uterine cervix tissue. -SCBT QC
Date published: 2015-04-11
Rated 5 out of 5 by HF from Robust band observed in western blot using ZRRobust band observed in western blot using ZR-75-1 whole cell lysate. -SCBT QC
Date published: 2015-04-09
Rated 5 out of 5 by MC from Clean band in human breast tissue extractClean band in human breast tissue extract by western blot. -SCBT QC
Date published: 2015-02-16
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Dvl-3/Dishevelled 3/DVL3 抗体 (C-3) is rated 5.0 out of 5 by 4.
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