m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for CS1 Antibody (162.1) for WB and IHC(P) applications. This reagent is now offered in a bundle with CS1 Antibody (162.1) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
CS1 Antibody (162.1) is a high quality monoclonal CS1 antibody (also designated CS1 antibody) suitable for the detection of the CS1 protein of mouse, rat and human origin. CS1 Antibody (162.1) is available as both the non-conjugated anti-CS1 antibody form, as well as multiple conjugated forms of anti-CS1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CS1, also known as novel Ly9, SLAMF7, 19A24 or CRACC, is a homophilic cell surface receptor. It is a member of the SLAM (signaling lymphocytic activation molecule) family of receptors expressed on natural killer (NK) cells, T cells and stimulated B cells. CS1 contains immunoreceptor tyrosine-based switch motifs in its cytoplasmic domain but, unlike other SLAM receptors, it does not recruit SAP (SLAM-associated protein). In humans, CS1 activates NK cells through an EAT-2-mediated pathway that is SAP-independent. CS1 recruits and associates with EAT-2, a protein closely related to SAP. EAT-2 induces phosphorylation of CS1 which then, upon ligand binding, activates downstream cytotoxicity effectors PLCγ and PI 3-kinase. In mice, the EAT-2 association with CS1 has an inhibitory effect on the activation of NK cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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