CREM Antibody (A-2): sc-377496
- CREM Antibody (A-2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against the full length polyhistidine tagged CREM fusion protein fusion protein of mouse origin
- recommended for detection of CREM of mouse and rat origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-377496 X, 200 µg/0.1 ml)
- See CREM (C-2): sc-390426 for CREM antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CREM Antibody (A-2) for WB applications. These reagents are now offered in bundles with CREM Antibody (A-2) (see ordering information below).
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CREM Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody specifically engineered to detect the cAMP response element modulator (CREM). CREM monoclonal antibody (A-2) is raised against the full-length polyhistidine-tagged CREM fusion protein and is effective in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CREM is a crucial member of the ATF/CREB family of transcription factors, predominantly localized in the nucleus where CREM plays a vital role in regulating gene expression by binding to cAMP response elements in promoter and enhancer regions. The nuclear presence of CREM is essential for controlling transcriptional activity, which influences key biological processes such as spermatogenesis and cellular responses to hormonal signaling. Additionally, CREM interacts with tissue-specific partners to ensure precise regulation of target genes, highlighting the importance of cellular localization. Anti-CREM antibody (A-2) also exhibits reactivity with CREM proteins from rat origin, expanding applicability in comparative studies across species. By enabling accurate detection and localization of CREM within cells, CREM monoclonal antibody (A-2) serves as an invaluable tool for researchers exploring cellular signaling pathways, gene regulation mechanisms, and reproductive biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CREM Antibody (A-2) References:
- Signaling routes to CREM and CREB: plasticity in transcriptional activation. | De Cesare, D., et al. 1999. Trends Biochem Sci. 24: 281-5. PMID: 10390618
- CREM, a master-switch of the transcriptional cascade in male germ cells. | De Cesare, D., et al. 2000. J Endocrinol Invest. 23: 592-6. PMID: 11079454
- Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT. | Fimia, GM., et al. 2001. Mol Cell Endocrinol. 179: 17-23. PMID: 11420126
- Transcription factor cAMP response element modulator (Crem) restrains Pdgf-dependent proliferation of vascular smooth muscle cells in mice. | Seidl, MD., et al. 2015. Pflugers Arch. 467: 2165-77. PMID: 25425331
- Primary Intracranial Mesenchymal Tumor with EWSR1-CREM Gene Fusion: A Case Report and Literature Review. | Liu, C., et al. 2020. World Neurosurg. 142: 318-324. PMID: 32668333
- Expression of Transcription Factor CREM in Human Tissues. | Kaprio, H., et al. 2021. J Histochem Cytochem. 69: 495-509. PMID: 34261344
- The cAMP responsive element modulator (CREM) is a regulator of CD4+ T cell function. | Subramanyam, SH. and Tenbrock, K. 2021. Biol Chem. 402: 1591-1596. PMID: 34448385
- FUS::CREM-rearranged malignant epithelioid neoplasm mimicking neuroendocrine neoplasm of unknown primary. | Demetter, P., et al. 2022. Histopathology. 80: 871-873. PMID: 34605068
- CREM Is Correlated With Immune-Suppressive Microenvironment and Predicts Poor Prognosis in Gastric Adenocarcinoma. | Yu, K., et al. 2021. Front Cell Dev Biol. 9: 697748. PMID: 34938728
- Ovarian epithelioid malignant peripheral nerve sheath tumor with EWSR1-CREM fusion: A case report and literature review. | Li, S., et al. 2023. Int J Gynaecol Obstet. 163: 521-527. PMID: 37151162
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CREM Antibody (A-2) | sc-377496 | 200 µg/ml | $322.00 | |||
CREM Antibody (A-2): m-IgG Fc BP-HRP Bundle | sc-538047 | 200 µg Ab; 10 µg BP | $361.00 | |||
CREM Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-535573 | 200 µg Ab; 40 µg BP | $361.00 | |||
CREM Antibody (A-2): m-IgG1 BP-HRP Bundle | sc-545499 | 200 µg Ab; 20 µg BP | $361.00 | |||
CREM Antibody (A-2) X | sc-377496 X | 200 µg/0.1 ml | $322.00 |