Date published: 2025-9-9

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Chitotriosidase 抗体 (A-3): sc-271282

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说明书
  • Chitotriosidase抗体(A-3)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 针对氨基酸150-215的图谱,在Chitotriosidase的内部区域,human起源
  • 推荐用于 human 来源的Chitotriosidase WB, IP, IF 和 ELISA检测
  • 2b BP-HRP">m-IgG2b BP-HRPm-IgGκ BP-HRP是Chitotriosidase Antibody (A-3) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Chitotriosidase Antibody (A-3) 打包提供(请参阅下面的订购信息)。

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    几丁质酶是一种普遍存在的几丁质片段水解酶。几丁质酶三糖酶能够切割人体内天然的几丁质和几丁质样底物,可能在抵抗含有几丁质的病原体的免疫中发挥作用。活化的人巨噬细胞分泌几丁质三糖酶,血浆中几丁质三糖酶水平升高是戈谢病患者的特征。小鼠几丁质三糖酶的表达仅限于脑、皮肤、骨髓、肾、舌、胃和睾丸。几丁质三糖酶与低等生物中发现的几丁质酶之间的同源性是显着的。酸性哺乳动物几丁质酶前体(AMCase)降解几丁三糖和几丁质。AMCase在胃组织中高度表达,主要是一种分泌蛋白。它参与Th2介导的炎症,可能在哮喘和过敏性疾病中发挥作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Chitotriosidase 抗体 (A-3) 参考文献:

    1. 人类壳三糖苷酶催化壳聚糖水解。  |  Eide, KB., et al. 2012. Biochemistry. 51: 487-95. PMID: 22192075
    2. 人类壳三糖苷酶 CHIT1 与哺乳动物类底物发生交叉反应。  |  Larsen, T., et al. 2014. FEBS Lett. 588: 746-51. PMID: 24462685
    3. 壳三糖苷酶酶活性在肾病性胱氨酸沉着症中的临床实用性。  |  Elmonem, MA., et al. 2014. Orphanet J Rare Dis. 9: 155. PMID: 25407738
    4. 壳三糖苷酶活性与结核病的关系  |  Chen, M., et al. 2015. Epidemiol Infect. 143: 3196-202. PMID: 26418349
    5. 血浆中的壳三糖苷酶活性与慢性阻塞性肺病恶化  |  Harlander, M., et al. 2020. Lung. 198: 299-306. PMID: 31982942
    6. 壳三糖苷酶活性和 CCL18 浓度在评估 I 型戈谢病严重程度中的准确性。对个体参与者数据进行系统回顾和荟萃分析。  |  Raskovalova, T., et al. 2021. Haematologica. 106: 437-445. PMID: 32001533
    7. 作为治疗监测肾病性胱氨酸沉积症的新型生物标记物的壳三糖苷酶  |  Veys, KRP., et al. 2020. J Am Soc Nephrol. 31: 1092-1106. PMID: 32273301
    8. 脊髓性肌萎缩症患者接受奴西那生治疗后,壳三糖苷酶 1 浓度升高。  |  Freigang, M., et al. 2021. Orphanet J Rare Dis. 16: 330. PMID: 34321067
    9. 急性胰腺炎患者的血清壳三糖苷酶和 YKL-40:作为疾病严重程度预后标志物的可靠性以及与炎症标志物的相关性。  |  Ünal Çetin, E., et al. 2021. Turk J Med Sci. 51: 3038-3046. PMID: 34579512
    10. 壳三糖苷酶是伴有轴突球和色素胶质的成人型白质脑病的生物标志物。  |  Hayer, SN., et al. 2022. Ann Clin Transl Neurol. 9: 1807-1812. PMID: 36271674

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Chitotriosidase 抗体 (A-3)

    sc-271282
    200 µg/ml
    $316.00

    Chitotriosidase (A-3): m-IgGκ BP-HRP 套装

    sc-534916
    200 µg Ab; 40 µg BP
    $354.00

    Chitotriosidase (A-3): m-IgG2b BP-HRP 套装

    sc-549314
    200 µg Ab; 10 µg BP
    $354.00

    Does this antibody work in fixed brain tissue and monkey using IHC?

    Asked by: sylviapa69
    Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
    Answered by: Technical Support
    Date published: 2021-07-22

    What blocking solution should I use with Chitotriosidase (A-3): sc-271282 monoclonal antibody for Western blot?

    Asked by: Trav11
    Thank you for your question. We recommend blocking with Blotto (either TBS Blotto A: sc-2333 or TBS Blotto B: sc-2335). Our Western blot protocol can be found here: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Produced nice Western blot data of ChitotriosidaseProduced nice Western blot data of Chitotriosidase expression in AML-193 whole cell lysate. -SCBT QC
    Date published: 2013-02-03
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    Chitotriosidase 抗体 (A-3) is rated 5.0 out of 5 by 1.
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