Date published: 2025-9-6
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Cdk7 Antibody (C-4) - Western Blotting - Image 354389
Cdk7 抗体 (C-4): sc-7344. HUV-EC-C (A), WI-38 (B), ARPE-19 (C), M1 (D), 3T3-L1 (E) 和 RPE-J (F) 全细胞裂解液中 Cdk7 表达的 Western 印迹分析.
Cdk7 抗体 (C-4): sc-7344. HUV-EC-C (A), WI-38 (B), ARPE-19 (C), M1 (D), 3T3-L1 (E) 和 RPE-J (F) 全细胞裂解液中 Cdk7 表达的 Western 印迹分析.

Cdk7 抗体 (C-4): sc-7344

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寫評論提問

说明书
  • Cdk7 抗体 C-4 是小鼠单克隆 IgG2a κ，Cdk7抗体, 在70篇文献中引用，规格为200 µg/ml
  • 免疫1-346氨基酸，对应于human来源Cdk7全长
  • Cdk7 抗体 (C-4) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 Cdk7
  • 抗Cdk7抗体（C-4）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还可偶联TRITC 用于IF, IHC(P) 和FCM
  • 关于如何获取Cdk7 (C-4): sc-7344的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRP 和 m-IgGκ BP-HRP 是 Cdk7 抗体 (C-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Cdk7 抗体 (C-4) 组合成套装提供。 (请参阅下面的订购信息)。

快捷链接

相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 Cdk 抗体 包括 Cdk1, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8和Cdk9

Cdk7抗体（C-4）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过多种应用检测小鼠、大鼠和人类来源的Cdk7蛋白，包括蛋白质印迹、免疫沉淀、免疫荧光、免疫组织化学和酶联免疫吸附测定。Cdk7 (C-4) 抗体有非结合型和多种结合型，如琼脂糖、辣根过氧化物酶、藻红蛋白、异硫氰酸荧光素和多种 Alexa Fluor® 结合物。作为细胞周期依赖性激酶激活激酶（CAK）复合物的一部分，Cdk7在细胞周期调节中发挥着至关重要的作用，而CAK复合物对于激活其他细胞周期依赖性激酶（包括Cdk2和Cdc2）至关重要。通过在特定的苏氨酸残基上对这些激酶进行磷酸化，Cdk7可确保细胞周期平稳进行，从而实现正常的细胞分裂和功能。Cdk7作为调控中枢，整合了各种信号通路，从而影响细胞对外部刺激的反应。鉴于其在细胞周期控制中的关键作用，Cdk7成为癌症生物学研究的重要目标，因为细胞周期进展失调是肿瘤形成的标志。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdk7 抗体 (C-4) 参考文献:

  1. 纯化 CDK7/CycH/MAT1, CDK8/CycC 和 CDK9/CycT1 的统一程序。  |  Pinhero, R., et al. 2004. Biol Proced Online. 6: 163-172. PMID: 15328539
  2. 人类 CDK7 的晶体结构及其蛋白质识别特性。  |  Lolli, G., et al. 2004. Structure. 12: 2067-79. PMID: 15530371
  3. 甘草酸通过干扰 CDK7 介导的 CDC2/p34 磷酸化，诱导人胃癌 BGC-823 细胞 G2/M 期细胞周期停滞。  |  Yu, J., et al. 2007. Carcinogenesis. 28: 632-8. PMID: 17012222
  4. 人类细胞化学遗传学揭示了 Cdk7 在组装 Cdk1/cyclin B 和激活 Cdk2 中的作用。  |  Larochelle, S., et al. 2007. Mol Cell. 25: 839-50. PMID: 17386261
  5. 类固醇生成因子 1 的磷酸化是由细胞周期蛋白依赖性激酶 7 介导的。  |  Lewis, AE., et al. 2008. Mol Endocrinol. 22: 91-104. PMID: 17901130
  6. CDK7抑制剂作为抗癌药物。  |  Sava, GP., et al. 2020. Cancer Metastasis Rev. 39: 805-823. PMID: 32385714
  7. CDK7控制多发性骨髓瘤中E2F和MYC驱动的增殖和代谢脆弱性。  |  Yao, Y., et al. 2023. Blood. 141: 2841-2852. PMID: 36877894
  8. CDK7-YAP-LDHD轴促进D-乳酸消除和铁死亡防御，以支持癌症干细胞样特性。  |  Lv, M., et al. 2023. Signal Transduct Target Ther. 8: 302. PMID: 37582812
  9. 小鼠 MO15 相关激酶对细胞周期蛋白依赖性激酶 4 (cdk4) 的激活作用  |  Matsuoka, M., et al. 1994. Mol Cell Biol. 14: 7265-75. PMID: 7935441
  10. 细胞周期蛋白与癌症。二：细胞周期蛋白 D 和 CDK 抑制剂的时代到来。  |  Hunter, T. and Pines, J. 1994. Cell. 79: 573-82. PMID: 7954824
  11. cdk4 激活激酶对细胞周期蛋白 D 依赖性激酶 4 (cdk4) 的调控。  |  Kato, JY., et al. 1994. Mol Cell Biol. 14: 2713-21. PMID: 8139570
  12. 与调节细胞周期的爪蟾 MO15 和 NIMA 激酶具有同源性的两种新型人类丝氨酸/苏氨酸激酶：克隆及其表达模式的表征。  |  Levedakou, EN., et al. 1994. Oncogene. 9: 1977-88. PMID: 8208544

订购信息

产品名称产品编号规格价格数量收藏夹

Cdk7 抗体 (C-4)

sc-7344
200 µg/ml
$316.00

Cdk7 (C-4): m-IgG Fc BP-HRP 套装

sc-528178
200 µg Ab; 10 µg BP
$354.00

Cdk7 (C-4): m-IgGκ BP-HRP 套装

sc-520495
200 µg Ab, 40 µg BP
$354.00

Cdk7 (C-4): m-IgG2a BP-HRP 套装

sc-547037
200 µg Ab; 10 µg BP
$354.00

Cdk7 抗体 (C-4) AC

sc-7344 AC
500 µg/ml, 25% agarose
$416.00

Cdk7 抗体 (C-4) HRP

sc-7344 HRP
200 µg/ml
$316.00

Cdk7 抗体 (C-4) FITC

sc-7344 FITC
200 µg/ml
$330.00

Cdk7 抗体 (C-4) PE

sc-7344 PE
200 µg/ml
$343.00

Cdk7 抗体 (C-4) Alexa Fluor® 488

sc-7344 AF488
200 µg/ml
$357.00

Cdk7 抗体 (C-4) Alexa Fluor® 546

sc-7344 AF546
200 µg/ml
$357.00

Cdk7 抗体 (C-4) Alexa Fluor® 594

sc-7344 AF594
200 µg/ml
$357.00

Cdk7 抗体 (C-4) Alexa Fluor® 647

sc-7344 AF647
200 µg/ml
$357.00

Cdk7 抗体 (C-4) Alexa Fluor® 680

sc-7344 AF680
200 µg/ml
$357.00

Cdk7 抗体 (C-4) Alexa Fluor® 790

sc-7344 AF790
200 µg/ml
$357.00

Cdk7 抗体 (C-4) TRITC

sc-7344 TRITC
200 µg/ml
$320.00

Can I use this mouse monoclonal antibody for immunohistochemical staining of mouse tissue? Or even double or triple staining on the same samples?

Asked by: DefinitelyNotMatt
Thank you for your question. Yes. We recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is currently available conjugated to phycoerythrin (sc-7344 PE), fluorescein (sc-7344 FITC), Alexa Fluor® 488 (sc-7344 AF488) or Alexa Fluor® 647 (sc-7344 AF647). Please contact Technical Service if you have further questions concerning this product.
Answered by: Technical Support 12
Date published: 2017-01-10
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Rated 5 out of 5 by from Anti CDK7 antibodiesThe antibody worked fine for us in various applications including immunoblots of total cell extracts.
Date published: 2018-06-20
Rated 5 out of 5 by from good for WBGave a robust band of correct MW on WB on growing human MRC5 fibroblasts.
Date published: 2018-04-04
Rated 3 out of 5 by from great antibody for western bloti got this antibody from Santa Cruz one month ago, it works well in MCF7 cells.
Date published: 2017-12-06
Rated 4 out of 5 by from Works for WBWorks well for WB. Would definitely recommend for this.
Date published: 2017-11-21
Rated 5 out of 5 by from WBThe purpose of our study is study the CDK7 protein levels by WB. We found the target protein level increased in ovarian cancer as compared with the nomal tissue.The antibody shows good quality at 1:800 dilution and no non-specific bands but specific bands at 40kda.
Date published: 2017-09-16
Rated 5 out of 5 by from good specificThis antibody reacts specific to Cdk7 in Hela cell. Strong signal obtained at 1:800 dilution by loading cell lysates 60ug.
Date published: 2017-09-02
Rated 5 out of 5 by from strong target bandloading 50ug mouse liver protein per lane, used at a concentration of 1:1000 dilution ,shows the target band after expose.
Date published: 2017-06-03
Rated 5 out of 5 by from Worked greatWorked great in WB with primary mouse brain(Dilution 1:400).
Date published: 2017-04-19
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Cdk7 抗体 (C-4) is rated 4.8 out of 5 by 20.
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