Cdk2 Antibody (0.N.198): sc-70829
- Cdk2 Antibody (0.N.198) is a mouse monoclonal IgG2a κ, cited in 8 publications, provided at 200 µg/ml
- raised against human recombinant Cdk2
- recommended for detection of Cdk2 of mouse, rat and human origin by WB and IP
- See Cdk2 (D-12): sc-6248 for Cdk2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2a BP-HRP is the preferred secondary detection reagent for Cdk2 Antibody (0.N.198) for WB applications. This reagent is now offered in a bundle with Cdk2 Antibody (0.N.198) (see ordering information below).
Cdk2 Antibody (0.N.198) is a mouse monoclonal IgG2a kappa light chain antibody designed to recognize Cyclin-dependent kinase 2 (Cdk2), a pivotal enzyme in cell cycle regulation. Anti-Cdk2 antibody (0.N.198) is raised against human recombinant Cdk2 and effectively detects Cdk2 from mouse, rat, and human species in western blotting (WB) and immunoprecipitation (IP) applications. Cdk2, also known simply as CDK2, plays a crucial role in controlling the transition from the G1 phase to the S phase and the progression through the S phase by forming complexes with cyclins E and A. These complexes are essential for the initiation of DNA replication and proper cell division. Post-translational modifications, such as phosphorylation at threonine 160, are critical for activating Cdk2, thereby regulating kinase activity and ensuring accurate cell cycle progression. The activation and regulation of Cdk2 are vital for maintaining genomic stability and preventing uncontrolled cell proliferation, making Cdk2 a significant target in cancer research and the development of therapeutic interventions. Additionally, Cdk2 interacts with other cyclin-dependent kinases, including Cdk3, Cdk8, PCTAIRE-1-3, and KKIALRE, underscoring Cdk2′s integral role in the intricate network of cell cycle control. Understanding the mechanisms governing Cdk2 activity and regulation is essential for elucidating the molecular pathways that drive cell growth and division, as well as for identifying potential points of intervention in diseases characterized by aberrant cell cycle regulation. Cdk2 monoclonal antibody (0.N.198) is an invaluable tool for researchers investigating these critical aspects of cellular biology and disease mechanisms.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk2 Antibody (0.N.198) | sc-70829 | 200 µg/ml | $322.00 | |||
Cdk2 Antibody (0.N.198): m-IgG2a BP-HRP Bundle | sc-546004 | 200 µg Ab; 10 µg BP | $361.00 |