CD38 Antibody (HB-7): sc-18858

CD38 Antibody (HB-7) is a mouse monoclonal IgG1 antibody that detects CD38 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD38 is a type II integral membrane glycoprotein predominantly expressed on early B and T cell lineages, activated B and T cells, and various other immune cells, including thymocytes, pre-B cells, and Ig-secreting plasma cells. CD38′s presence on these cells is crucial for immune response regulation, as CD38 functions as a NAD glycohydrolase, facilitating the production of calcium-mobilizing metabolites like cyclic adenosine diphosphate ribose (cADPR). CD38′s enzymatic activity is vital for the activation, proliferation, and differentiation of mature T and B cells, as well as for mediating apoptosis in myeloid and lymphoid progenitor cells. Furthermore, CD38 plays a significant role in maintaining the survival of invariant natural killer T (iNKT) cells, which are essential for sustaining immunological tolerance. Anti-CD38 antibody (HB-7) is an invaluable tool for researchers studying immune cell dynamics and the intricate signaling pathways that govern immune responses.

The preferred CD38 antibody is CD38 Antibody (AT13/5): sc-59028.