Date published: 2025-9-7

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β-TrCP 抗体 (C-6): sc-390629

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说明书
  • beta-TrCP 抗体 C-6 是小鼠单克隆 IgG2a κ,β-TrCP抗体, 在19篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列26-110位于human物种的β-TrCP isoforms 1 and 2的N-terminus附近
  • beta-TrCP 抗体 (C-6) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 β-TrCP isoforms 1 and 2; 也和以下物种反应,包括: 和 equine, canine and porcine
  • 抗beta-TrCP抗体(C-6)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取β-TrCP (C-6): sc-390629免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是β-TrCP Antibody (C-6) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与β-TrCP Antibody (C-6) 打包提供(请参阅下面的订购信息)。

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関連項目

β-TrCP抗体(C-6)是一种IgG2a κ小鼠单克隆β-TrCP抗体(也被指定为包含E3泛素蛋白连接酶抗体的β-转导素重复,BTRC抗体,βTrCP1抗体,含F-box/WD重复序列的蛋白质1A(FBXW1A)抗体,FBW1A抗体,FBXW1抗体,betaTrCP抗体,泛素蛋白连接酶复合物亚基抗体,或磷酸化依赖性泛素途径相关抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类的β-TrCP蛋白。β-TrCP抗体(C-6)既可以作为非共轭的抗β-TrCP抗体形式,也可以作为多种共轭形式的抗β-TrCP抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®共轭物。β-TrCP(含有β-tranducin重复序列的蛋白),也被指定为E3RSIkB或FWD1,和HOS(与Slimb同源)是F-box蛋白,作为泛素连接酶的底物识别亚基发挥作用。HOS和β-TrCP在它们的氨基末端区域不同,但在F-box和包含WD40重复序列的区域内表现出高度同源性。β-TrCP介导CD4的泛素/蛋白酶体依赖性降解以及各种蛋白质(包括IkB和β-catenin)的泛素化。HOS也被证明以类似的方式调节IkB和β-catenin的降解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

β-TrCP 抗体 (C-6) 参考文献:

  1. IkappaBalpha 的泛素依赖性降解是由泛素连接酶 Skp1/Cul 1/F-box 蛋白 FWD1 介导的。  |  Hatakeyama, S., et al. 1999. Proc Natl Acad Sci U S A. 96: 3859-63. PMID: 10097128
  2. HOS 是 Slimb 的人类同源物,它与 Skp1 和 Cullin1 形成 SCF 复合物,靶向磷酸化依赖性降解 IkappaB 和 beta-catenin。  |  Fuchs, SY., et al. 1999. Oncogene. 18: 2039-46. PMID: 10321728
  3. Lats和CK1的协调磷酸化通过SCF(β-TRCP)调节YAP的稳定性。  |  Zhao, B., et al. 2010. Genes Dev. 24: 72-85. PMID: 20048001
  4. 环状 RNA circPVT1 通过 β-TrCP/c-Myc/SRSF1 正反馈环促进鼻咽癌转移  |  Mo, Y., et al. 2022. Mol Cancer. 21: 192. PMID: 36199071
  5. SDCBP 通过阻止 YAP1 在 β-TrCP 介导下被蛋白酶体降解,从而促进胰腺癌的进展。  |  Liu, J., et al. 2023. Gut. 72: 1722-1737. PMID: 36828627
  6. 全反式维甲酸促进食管鳞状细胞癌的抑瘤OTUD6B-β-TrCP-SNAIL轴并增强免疫疗法  |  Li, L., et al. 2023. Adv Sci (Weinh). 10: e2207458. PMID: 37038094
  7. 隐藏在环形 RNA 中的新型 β-TrCP 蛋白异构体使 HER2 阳性乳腺癌产生曲妥珠单抗抗药性。  |  Wang, S., et al. 2023. Redox Biol. 67: 102896. PMID: 37783059
  8. 特异性靶向 NRF2/β-TrCP 轴可对 NASH 产生有益影响。  |  Fernández-Ginés, R., et al. 2024. Redox Biol. 69: 103027. PMID: 38184999
  9. 抑制 MST1 可通过 GSK3β/β-TrCP/NRF2 通路改善糖尿病伴脊髓损伤的神经细胞凋亡。  |  Huang, W., et al. 2024. Redox Biol. 71: 103104. PMID: 38430683
  10. 一种新型人类 WD 蛋白--h-beta TrCp--能与 HIV-1 Vpu 相互作用,通过 F-box motif 将 CD4 连接到 ER 降解途径。  |  Margottin, F., et al. 1998. Mol Cell. 1: 565-74. PMID: 9660940
  11. SCF 泛素蛋白连接酶底物识别亚基的泛素化和降解。  |  Zhou, P. and Howley, PM. 1998. Mol Cell. 2: 571-80. PMID: 9844630
  12. 鉴定 IkappaBalpha-泛素连接酶的受体成分。  |  Yaron, A., et al. 1998. Nature. 396: 590-4. PMID: 9859996

订购信息

产品名称产品编号规格价格数量收藏夹

β-TrCP 抗体 (C-6)

sc-390629
200 µg/ml
$316.00

β-TrCP (C-6): m-IgG Fc BP-HRP 套装

sc-530206
200 µg Ab; 10 µg BP
$354.00

β-TrCP (C-6): m-IgGκ BP-HRP 套装

sc-523609
200 µg Ab, 40 µg BP
$354.00

β-TrCP (C-6): m-IgG2a BP-HRP 套装

sc-547456
200 µg Ab; 10 µg BP
$354.00

β-TrCP 抗体 (C-6) AC

sc-390629 AC
500 µg/ml, 25% agarose
$416.00

β-TrCP 抗体 (C-6) HRP

sc-390629 HRP
200 µg/ml
$316.00

β-TrCP 抗体 (C-6) FITC

sc-390629 FITC
200 µg/ml
$330.00

β-TrCP 抗体 (C-6) PE

sc-390629 PE
200 µg/ml
$343.00

β-TrCP 抗体 (C-6) Alexa Fluor® 488

sc-390629 AF488
200 µg/ml
$357.00

β-TrCP 抗体 (C-6) Alexa Fluor® 546

sc-390629 AF546
200 µg/ml
$357.00

β-TrCP 抗体 (C-6) Alexa Fluor® 594

sc-390629 AF594
200 µg/ml
$357.00

β-TrCP 抗体 (C-6) Alexa Fluor® 647

sc-390629 AF647
200 µg/ml
$357.00

β-TrCP 抗体 (C-6) Alexa Fluor® 680

sc-390629 AF680
200 µg/ml
$357.00

β-TrCP 抗体 (C-6) Alexa Fluor® 790

sc-390629 AF790
200 µg/ml
$357.00

Can this antibody be used for IF?What's the dilution range?

Asked by: zzzzb
Thank you for your question. This antibody is recommended for IF experiments on cells as well as frozen sections. It is not recommended for paraffin sections. The dilution range is 1:50-1:500. Thank you.
Answered by: Jiajun Z
Date published: 2024-07-11

Are there any issues with using sc-390629: ∫-TrCP (C-6) mouse monoclonal primary antibody on mouse samples?

Asked by: Dr Ninau Qelp
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-390629 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 2 out of 5 by from Very weak bandIt showed a very weak band by western blot in HEK 293T cells.
Date published: 2018-10-25
Rated 5 out of 5 by from great performanceI have tested the sample, and soon after the test I've decided to purchase the full vial.
Date published: 2018-09-24
Rated 5 out of 5 by from Positive resultsObserved nice and specific Western blot band with beta-TrCP Antibody (C-6) in multiple samples
Date published: 2017-01-27
Rated 5 out of 5 by from Satisfactory Western Blot data ofSatisfactory Western Blot data of -TrCP expression in MDA-MB-435S, ZR-75-1 and Ramos whole cell lysates. -SCBT QC
Date published: 2015-01-29
Rated 5 out of 5 by from Produced positive Western Blot data ofProduced positive Western Blot data of -TrCP expression in HeLa whole cell lysate. -SCBT QC
Date published: 2014-10-28
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β-TrCP抗体 (C-6) is rated 4.4 out of 5 by 5.
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