Aquaporin 2/AQP2 Antibody (G-3): sc-515798
- Aquaporin 2/AQP2 Antibody (G-3) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 232-271 within a C-terminal cytoplasmic domain of AQP2 of human origin
- recommended for detection of AQP2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Aquaporin 2/AQP2 Antibody (G-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with Aquaporin 2/AQP2 Antibody (G-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
AQP2 Antibody (G-3) is a mouse monoclonal IgG2a antibody that detects aquaporin 2 (AQP2) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). AQP2 plays a crucial role in regulating water balance in the body, primarily functioning as a water channel in kidney collecting ducts, where AQP2 is responsible for water reabsorption in response to vasopressin. This process is vital for maintaining homeostasis, particularly during dehydration or increased plasma osmolality. Proper functioning of AQP2 is essential for urine concentration and prevention of water loss, making AQP2 a key player in renal physiology. Dysregulation of AQP2 can lead to various disorders, including nephrogenic diabetes insipidus, characterized by the inability to concentrate urine and excessive urination. Anti-AQP2 antibody (G-3) serves as an invaluable tool for researchers studying water transport mechanisms and related pathologies, providing insights into the molecular underpinnings of kidney function and fluid homeostasis.
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Aquaporin 2/AQP2 Antibody (G-3) References:
- Polarized Trafficking of AQP2 Revealed in Three Dimensional Epithelial Culture. | Rice, WL., et al. 2015. PLoS One. 10: e0131719. PMID: 26147297
- AQP2 Plasma Membrane Diffusion Is Altered by the Degree of AQP2-S256 Phosphorylation. | Arnspang, EC., et al. 2016. Int J Mol Sci. 17: PMID: 27801846
- Ezrin directly interacts with AQP2 and promotes its endocytosis. | Li, W., et al. 2017. J Cell Sci. 130: 2914-2925. PMID: 28754689
- NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation. | Trimpert, C., et al. 2017. PLoS One. 12: e0183774. PMID: 28931009
- Structural Insights into AQP2 Targeting to Multivesicular Bodies. | Roche, JV., et al. 2019. Int J Mol Sci. 20: PMID: 31661793
- Statins ameliorate cholesterol-induced inflammation and improve AQP2 expression by inhibiting NLRP3 activation in the kidney. | Kong, Y., et al. 2020. Theranostics. 10: 10415-10433. PMID: 32929357
- HDAC3 inhibition improves urinary-concentrating defect in hypokalaemia by promoting AQP2 transcription. | Xu, L., et al. 2022. Acta Physiol (Oxf). 234: e13802. PMID: 35178888
- Pkd2 Deficiency in Embryonic Aqp2 + Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease. | Tsilosani, A., et al. 2024. J Am Soc Nephrol. 35: 398-409. PMID: 38254271
- Modulation of AQP2 localization and water reabsorption. | Empitu, MA., et al. 2024. J Physiol. 602: 1665-1667. PMID: 38520369
- Activation of TGR5 Increases Urine Concentration by Inducing AQP2 and AQP3 Expression in Renal Medullary Collecting Ducts. | Guo, Y., et al. 2024. Kidney Dis (Basel). 10: 181-192. PMID: 38835402
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aquaporin 2/AQP2 Antibody (G-3) | sc-515798 | 200 µg/ml | $322.00 | |||
Aquaporin 2/AQP2 Antibody (G-3): m-IgGκ BP-HRP Bundle | sc-525223 | 200 µg Ab, 40 µg BP | $361.00 |