17β-HSD Antibody (A-5): sc-376719

17β-HSD Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 17β-HSD plays a crucial role in steroid metabolism, catalyzing the conversion of estrone to estradiol and androstenedione to testosterone, which are vital processes in reproductive health and hormonal balance. 17β-HSD is predominantly expressed in ovarian granulosa cells and breast tissue, but can also be found in the testis, placenta, uterus, prostate, and adipose tissue, highlighting its significance in various physiological contexts. Notably, 17β-HSD functions as a homodimer and exhibits a preference for NADP(H) over NAD(H) during catalytic activity, which is essential for maintaining the redox state within cells. The gene encoding human 17β-HSD is located on chromosome 17q12-q21, and expression levels have been linked to breast cancer prognosis; patients with amplified 17β-HSD expression often experience poorer outcomes, particularly in the context of tamoxifen treatment. This underscores the potential of targeting 17β-HSD for therapeutic strategies in breast cancer, making anti-17β-HSD antibody (A-5) a valuable tool for researchers investigating its role in cancer biology and hormone regulation.

The preferred 17β-HSD antibody is 17β-HSD Antibody (D-8): sc-373902.