HLA-D激活剂

There are several types of compounds known to have effects that could indirectly increase the expression or functionality of MHC class II molecules, including HLA-D variants like HLA-DR, HLA-DQ, and HLA-DP. The mechanisms of action for these activators could be direct, where the compounds bind to specific domains on HLA-D molecules to improve their stability or peptide-loading capabilities. Alternatively, the action could be indirect, affecting signaling pathways or other cellular processes that lead to increased expression or functionality of HLA-D molecules.

Human Leukocyte Antigen D (HLA-D) molecules are a subset of major histocompatibility complex (MHC) class II proteins found primarily on the surface of antigen-presenting cells such as dendritic cells, B cells, and macrophages. They play an essential role in the adaptive immune system by presenting exogenously-derived antigenic peptides to CD4+ T cells. HLA-D is not a single molecule but rather a group of molecules, including HLA-DR, HLA-DP, and HLA-DQ, each with their own set of alleles. These molecules are composed of two chains: an α chain and a β chain, which together form a peptide-binding groove. The peptides presented by HLA-D molecules are typically found in pathogens or other exogenous substances that have been internalized and processed by the antigen-presenting cell. Once loaded with the appropriate peptide, the HLA-D molecule travels to the cell surface, where it can interact with T cell receptors, initiating a series of signaling events that lead to T cell activation and differentiation