MRP2 Antibody (B-11): sc-518047

MRP2 Antibody (B-11) is a mouse monoclonal IgG2b light chain antibody that detects MRP2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP2, also known as the canalicular multispecific organic anion transporter, plays a crucial role in the excretion of various organic anions, including drugs and toxins, from hepatocytes into bile, thereby contributing to the detoxification processes in the liver. MRP2 is predominantly localized to the apical membrane of hepatocytes, where high expression is essential for maintaining bile flow and preventing the accumulation of potentially harmful substances within the liver. Proper functioning of MRP2 is vital for drug metabolism and clearance, and dysfunction can lead to drug-induced liver injury and cholestasis, highlighting its importance in pharmacology and toxicology. Anti-MRP2 antibody (B-11) is an invaluable tool for researchers studying multidrug resistance and liver function, providing insights into the mechanisms of drug transport and the potential implications for therapeutic interventions.

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MRP2 Antibody (B-11) References:

1. Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense.  |  Leslie, EM., et al. 2005. Toxicol Appl Pharmacol. 204: 216-37. PMID: 15845415
2. Involvement of Mrp2/MRP2 in the species different excretion route of benzylpenicillin between rat and human.  |  Choi, MK., et al. 2009. Xenobiotica. 39: 171-81. PMID: 19255943
3. In Vitro Transport Activity and Trafficking of MRP2/ABCC2 Polymorphic Variants.  |  Wen, X., et al. 2017. Pharm Res. 34: 1637-1647. PMID: 28405913
4. Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models.  |  Oh, JH., et al. 2019. Asian J Pharm Sci. 14: 621-630. PMID: 32104488
5. Intraluminal nutrients acutely strengthen rat intestinal MRP2 barrier function by a glucagon-like peptide-2-mediated mechanism.  |  Tocchetti, GN., et al. 2020. Acta Physiol (Oxf). 230: e13514. PMID: 32476256
6. Tanshinone IIA attenuates acetaminophen-induced hepatotoxicity through HOTAIR-Nrf2-MRP2/4 signaling pathway.  |  Zhang, X., et al. 2020. Biomed Pharmacother. 130: 110547. PMID: 32777703
7. Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity of mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence.  |  Li, X., et al. 2020. Toxicol Appl Pharmacol. 409: 115332. PMID: 33171190
8. Multidrug resistance-associated protein 2 (MRP2) is an efflux transporter of EGCG and its metabolites in the human small intestine.  |  Kikuchi, T., et al. 2022. J Nutr Biochem. 107: 109071. PMID: 35636688
9. Hepatic canalicular membrane 5: Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver.  |  Keppler, D. and Konig, J. 1997. FASEB J. 11: 509-16. PMID: 9212074
10. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance protein MRP1 and its apical isoform MRP2.  |  Keppler, D., et al. 1998. Chem Biol Interact. 111-112: 153-61. PMID: 9679551

The preferred MRP2 antibody is MRP2 Antibody (G-1): sc-518048.