MRP2 Antibody (G-1): sc-518048

MRP2 Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MRP2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP2 Antibody (G-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MRP2, also known as canalicular multispecific organic anion transporter, plays a crucial role in the excretion of a wide range of endogenous and exogenous compounds, including drugs and toxins, from hepatocytes into bile. This function is vital for maintaining cellular homeostasis and protecting the liver from potential damage caused by harmful substances. MRP2 is predominantly localized to the apical membrane of hepatocytes, where MRP2 facilitates the transport of organic anions, thereby contributing to the detoxification processes in the liver. Expression of MRP2 is constitutively high in normal liver cells, and MRP2 activity is essential for the proper clearance of various therapeutic agents, making MRP2 a significant target for studies related to drug metabolism and resistance in cancer therapy. Understanding the function and regulation of MRP2 can provide insights into the mechanisms of drug interactions and the development of multidrug resistance in cancer cells, highlighting MRP2′s importance in pharmacology and toxicology research.

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MRP2 Antibody (G-1) References:

1. MRP2 (ABCC2) and cisplatin sensitivity in hepatocytes and human ovarian carcinoma.  |  Guminski, AD., et al. 2006. Gynecol Oncol. 100: 239-46. PMID: 16213010
2. Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.  |  Ieiri, I., et al. 2009. Expert Opin Drug Metab Toxicol. 5: 703-29. PMID: 19442037
3. Decreased Mrp2 transport in severe macrovesicular fatty liver grafts.  |  Kudo, A., et al. 2012. J Surg Res. 178: 915-21. PMID: 22613706
4. Genistein and Glyceollin Effects on ABCC2 (MRP2) and ABCG2 (BCRP) in Caco-2 Cells.  |  Schexnayder, C. and Stratford, RE. 2015. Int J Environ Res Public Health. 13: ijerph13010017. PMID: 26703673
5. Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer.  |  Myint, K., et al. 2019. Sci Rep. 9: 2245. PMID: 30783141
6. Novel Mechanisms of Valproate Hepatotoxicity: Impaired Mrp2 Trafficking and Hepatocyte Depolarization.  |  Fu, D., et al. 2019. Toxicol Sci. 171: 431-442. PMID: 31368504
7. Glucosamine reverses drug resistance in MRP2 overexpressing ovarian cancer cells.  |  Valinezhad Sani, F., et al. 2020. Eur J Pharmacol. 868: 172883. PMID: 31866406
8. The effect of IL-1β on MRP2 expression and tamoxifen toxicity in MCF-7 breast cancer cells.  |  Valinezhad Sani, F., et al. 2021. Breast Dis. 40: 263-268. PMID: 34092579
9. Kaempferol suppression of acute colitis is regulated by the efflux transporters BCRP and MRP2.  |  Liu, Y., et al. 2022. Eur J Pharm Sci. 179: 106303. PMID: 36252521
10. Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione.  |  Ballatori, N. and Rebbeor, JF. 1998. Semin Liver Dis. 18: 377-87. PMID: 9875555

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MRP2 Antibody (G-1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MRP2 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MRP2 Antibody (G-1) Specifications

Alternate Product Name: MRP2

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 212-236

Epitope Target: MRP2

Epitope Species: human

Product Reactivity/Detection: MRP2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MRP2 Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin