I kappa B-beta Antibody (F-9): sc-390622
- IκB-β Antibody (F-9) is a mouse monoclonal IgM κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of IκB-β of mouse origin
- recommended for detection of IκB-β of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for IκB-β Antibody (F-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with IκB-β Antibody (F-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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IκB-β Antibody (F-9) is a mouse monoclonal IgM antibody that detects IκB-β in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IκB-β plays a crucial role in regulating the NF-κB signaling pathway, which controls immune responses, inflammation, and cell survival. By sequestering NF-κB dimers in the cytoplasm, IκB-β prevents their translocation to the nucleus, thereby inhibiting the transcription of target genes involved in these processes. IκB-β′s importance extends beyond regulatory function; post-translational modifications, such as phosphorylation, can influence stability and interaction with NF-κB. These modifications are critical for timely activation and resolution of immune responses, highlighting IκB-β′s significance in maintaining cellular homeostasis and responding to various stimuli. Anti-IκB-β antibody (F-9) provides valuable insights into NF-κB signaling dynamics for researchers studying immune regulation and related pathologies.
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I kappa B-beta Antibody (F-9) References:
- X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. | Malek, S., et al. 2003. J Biol Chem. 278: 23094-100. PMID: 12686541
- Requirement of an IkappaB-beta COOH terminal region protein for acidic-adaptation in CHO cells. | Lao, Q., et al. 2006. J Cell Physiol. 207: 238-43. PMID: 16331684
- Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta. | Xu, S., et al. 2006. Am J Physiol Cell Physiol. 291: C1336-45. PMID: 16822942
- A new regulatory mechanism of NF-kappaB activation by I-kappaBbeta in cancer cells. | Kim, JM., et al. 2008. J Mol Biol. 384: 756-65. PMID: 18950638
- Analysis of SRrp86-regulated alternative splicing: control of c-Jun and IκBβ activity. | Solis, AS. and Patton, JG. 2010. RNA Biol. 7: 486-94. PMID: 20400856
- IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response. | Rao, P., et al. 2010. Nature. 466: 1115-9. PMID: 20740013
- IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo. | Scheibel, M., et al. 2010. J Exp Med. 207: 2621-30. PMID: 20975042
- IκBβ is a positive and negative regulator of NF-κB activity during inflammation. | Kamata, H., et al. 2010. Cell Res. 20: 1178-80. PMID: 20975741
- miR-20a regulates inflammatory in osteoarthritis by targeting the IκBβ and regulates NK-κB signaling pathway activation. | Zhao, H. and Gong, N. 2019. Biochem Biophys Res Commun. 518: 632-637. PMID: 31451219
- Phosphorylation of the PEST domain of IkappaBbeta regulates the function of NF-kappaB/IkappaBbeta complexes. | McKinsey, TA., et al. 1997. J Biol Chem. 272: 22377-80. PMID: 9278383
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IκB-β Antibody (F-9) | sc-390622 | 200 µg/ml | $322.00 | |||
IκB-β Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-552533 | 200 µg Ab; 40 µg BP | $361.00 | |||
IκB-β (F-9) Neutralizing Peptide | sc-390622 P | 100 µg/0.5 ml | $69.00 |