ferritin heavy chain Antibody (C6): sc-517438

Ferritin heavy chain Antibody (C6) is a mouse monoclonal IgG2b antibody that detects ferritin heavy chain in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Ferritin heavy chain plays a crucial role in iron metabolism, primarily by catalyzing the oxidation of ferrous iron (FeII) to ferric iron (FeIII), which is essential for safe iron storage within cells. This process prevents the toxic effects of free iron and contributes to overall iron-buffering capacity of cells, ensuring iron availability for vital biological processes such as hemoglobin synthesis and cellular respiration. Additionally, ferritin heavy chain is implicated in thymidine biosynthesis regulation by enhancing cytoplasmic serine hydroxymethyltransferase expression, a key enzyme in thymidylate synthesis critical for DNA replication and repair. Ferritin heavy chain′s ability to modulate iron levels and influence cellular metabolism underscores its importance in maintaining cellular homeostasis and responding to oxidative stress, making anti-ferritin heavy chain antibody (C6) an invaluable tool for researchers studying iron metabolism and related pathologies.

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ferritin heavy chain Antibody (C6) References:

1. Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS.  |  Pitcher, J., et al. 2010. J Neuroimmunol. 224: 66-71. PMID: 20627326
2. Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress.  |  Cheng, HT., et al. 2015. Biochim Biophys Acta. 1850: 2506-17. PMID: 26423448
3. Ferritin heavy chain is a negative regulator of ovarian cancer stem cell expansion and epithelial to mesenchymal transition.  |  Lobello, N., et al. 2016. Oncotarget. 7: 62019-62033. PMID: 27566559
4. Ferritin heavy chain as a molecular imaging reporter gene in glioma xenografts.  |  Cheng, S., et al. 2017. J Cancer Res Clin Oncol. 143: 941-951. PMID: 28247036
5. Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain.  |  Mukherjee, C., et al. 2020. Cell Metab. 32: 259-272.e10. PMID: 32531201
6. Ferritin heavy chain (FTH1) exerts significant antigrowth effects in breast cancer cells by inhibiting the expression of c-MYC.  |  Ali, A., et al. 2021. FEBS Open Bio. 11: 3101-3114. PMID: 34551213
7. Production of Recombinant Human Hybrid Ferritin with Heavy Chain and Light Chain in Escherichia coli and its Characterization.  |  Song, X., et al. 2023. Curr Pharm Biotechnol. 24: 341-349. PMID: 35585819
8. Nuclear Factor Kappa B Promotes Ferritin Heavy Chain Expression in Bombyx mori in Response to B. mori Nucleopolyhedrovirus Infection.  |  Zhu, L., et al. 2022. Int J Mol Sci. 23: PMID: 36142290
9. miR-29a-5p modulates ferroptosis by targeting ferritin heavy chain FTH1 in prostate cancer.  |  Yang, G., et al. 2023. Biochem Biophys Res Commun. 652: 6-13. PMID: 36806086
10. WDR45 mutation dysregulates iron homeostasis by promoting the chaperone-mediated autophagic degradation of ferritin heavy chain in an ER stress/p38 dependent mechanism.  |  Xiong, Q., et al. 2023. Free Radic Biol Med. 201: 89-97. PMID: 36940732

The preferred ferritin heavy chain antibody is ferritin heavy chain Antibody (B-12): sc-376594.