Date published: 2025-9-8

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ferritin heavy chain Anticorpo (B-12): sc-376594

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  • ferritin heavy chain Anticorpo B-12é um anticorpo monoclonal produzido em camundongo IgG2a κ ferritin heavy chain anticorpo, citado em 79 publicações, fornecido em 200 µg/ml
  • Produzido contra aminoácidos 131-183 de ferritin heavy chain de human origem
  • ferritin heavy chain Anticorpo (B-12) é recomendado para a detecção de ferritin heavy chain de mouse, rat e human origem em WB, IP, IF e ELISA
  • Anticorpo anti-ferritin heavy chain O anticorpo anti-ferritin heavy chain (B-12) está disponível conjugado com agarose para IP; HRP para WB, IHC(P) e ELISA; e com fioeritrina ou FITC para IF, IHC(P) e FCM
  • também disponível conjugado com Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 para WB (RGB), IF, IHC(P) e FCM, e para utilização com sistemas de imagiologia fluorescente RGB, tais como iBright™ FL1000, FluorChem™, Typhoon, Azure e outros sistemas comparáveis
  • também disponível conjugado com Alexa Fluor® 680 ou Alexa Fluor® 790 para WB (NIR), IF e FCM; para utilização com sistemas de deteção de infravermelhos próximos (NIR), tais como LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure e outros sistemas comparáveis
  • Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de ferritin heavy chain (B-12): sc-376594.
  • 2a BP-HRP">m-IgG2a BP-HRP e m-IgGκ BP-HRP são os reagentes de deteção secundários preferidos para ferritin heavy chain Antibody (B-12) para aplicações WB. Estes reagentes são agora oferecidos em conjuntos com ferritin heavy chain Antibody (B-12)(ver informações de encomenda abaixo).

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VEJA TAMBÉM

O anticorpo de cadeia pesada de ferritina (B-12) é um anticorpo monoclonal de cadeia pesada de ferritina de camundongo IgG2a κ (também designado anticorpo de cadeia pesada de ferritina 1 ou anticorpo FHC) que detecta a proteína de cadeia pesada de ferritina de origem de camundongo, rato e humana por WB, IP, IF e ELISA. O anticorpo de cadeia pesada de ferritina (B-12) está disponível na forma de anticorpo antiferritina de cadeia pesada não conjugado, bem como em várias formas conjugadas de anticorpo antiferritina de cadeia pesada, incluindo agarose, HRP, PE, FITC e vários conjugados Alexa Fluor®. As ferritinas de mamíferos consistem em 24 subunidades compostas por dois tipos de cadeias polipeptídicas, a cadeia pesada de ferritina e a cadeia leve de ferritina, cada uma com funções exclusivas. As cadeias pesadas da ferritina catalisam a primeira etapa do armazenamento de ferro, a oxidação do FeII, enquanto as cadeias leves da ferritina promovem a nucleação da ferriidrita, permitindo o armazenamento do FeIII. A função mais importante das ferritinas mamma-lian é fornecer capacidade de tamponamento de ferro às células. Além do tamponamento de ferro, a ferritina de cadeia pesada também está envolvida na regulação da biossíntese de timidina por meio da expressão elevada da serina hidroximetiltransferase citoplasmática, que é um fator limitante na síntese de timidilato nas células MCF-7. A ferritina de cadeia leve está envolvida em cataratas por pelo menos dois mecanismos: síndrome de catarata por hiperferritinemia hereditária, na qual a ferritina de cadeia leve é superexpressa; e estresse oxidativo, um fator importante no desenvolvimento de cataratas relacionadas ao envelhecimento.

Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.

Alexa Fluor® é uma marca comercial da Molecular Probes Inc., OR., EUA

LI-COR® e Odyssey® são marcas registadas da LI-COR Biosciences

Referencias do ferritin heavy chain Anticorpo (B-12):

  1. Alto nível de mRNA da cadeia leve da ferritina no cristalino.  |  Cheng, Q., et al. 2000. Biochem Biophys Res Commun. 270: 349-55. PMID: 10753629
  2. A ferritina de cadeia pesada aumenta a expressão da serina hidroximetiltransferase e a biossíntese de novo da timidina.  |  Oppenheim, EW., et al. 2001. J Biol Chem. 276: 19855-61. PMID: 11278996
  3. O sulfureto é um agente eficaz de libertação de ferro para as ferritinas dos mamíferos.  |  Cassanelli, S. and Moulis, J. 2001. Biochim Biophys Acta. 1547: 174-82. PMID: 11343803
  4. Regulação da cadeia pesada de ferritina neuronal, um novo ator na disfunção de quimiocinas induzida por opiáceos.  |  Abt, AC. and Meucci, O. 2011. J Neuroimmune Pharmacol. 6: 466-76. PMID: 21465240
  5. Contra-ação da deficiência de cadeia pesada de ferritina do miocárdio pela Heme Oxigenase-1.  |  Machado, SE., et al. 2022. Int J Mol Sci. 23: PMID: 35955444
  6. Ferritin Heavy Chain Binds Peroxiredoxin 6 and Inhibits Cell Proliferation and Migration (Cadeia Pesada de Ferritina Liga-se à Peroxiredoxina 6 e Inibe a Proliferação e Migração Celular).  |  Di Sanzo, M., et al. 2022. Int J Mol Sci. 23: PMID: 36361777
  7. Cadeia Pesada de Ferritina Exossomal Derivada de Macrófagos M2 Promove a Proliferação de Células de Cancro do Cólon.  |  Cui, Z., et al. 2023. Biol Trace Elem Res. 201: 3717-3728. PMID: 36418633
  8. A cadeia pesada de ferritina participou na melhoria do stress oxidativo induzido pelo ácido 3-nitropropiónico e na apoptose das células granulosas foliculares de ganso.  |  Jiang, D., et al. 2023. Poult Sci. 102: 102606. PMID: 36940654
  9. Variantes heterozigóticas sem sentido no gene da cadeia pesada da ferritina FTH1 causam uma neuroferritinopatia.  |  Shieh, JT., et al. 2023. HGG Adv. 4: 100236. PMID: 37660254
  10. A cadeia pesada de ferritina apoia a estabilidade e a função da linhagem de células T reguladoras.  |  Wu, Q., et al. 2024. EMBO J. 43: 1445-1483. PMID: 38499786
  11. Atribuição dos genes da ferritina humana aos cromossomas 11 e 19q13.3----19qter.  |  Worwood, M., et al. 1985. Hum Genet. 69: 371-4. PMID: 3857215
  12. Comparação das estruturas tridimensionais das ferritinas recombinantes H humana e L de cavalo em alta resolução.  |  Hempstead, PD., et al. 1997. J Mol Biol. 268: 424-48. PMID: 9159481

Informacoes sobre ordens

Nome do ProdutoNumero de CatalogoUNIDPrecoQdeFAVORITOS

ferritin heavy chain Anticorpo (B-12)

sc-376594
200 µg/ml
$316.00

Pacote do ferritin heavy chain (B-12): m-IgGκ BP-HRP

sc-523022
200 µg Ab, 40 µg BP
$354.00

Pacote do ferritin heavy chain (B-12): m-IgG2a BP-HRP

sc-546133
200 µg Ab; 10 µg BP
$354.00

ferritin heavy chain Anticorpo (B-12) AC

sc-376594 AC
500 µg/ml, 25% agarose
$416.00

ferritin heavy chain Anticorpo (B-12) HRP

sc-376594 HRP
200 µg/ml
$316.00

ferritin heavy chain Anticorpo (B-12) FITC

sc-376594 FITC
200 µg/ml
$330.00

ferritin heavy chain Anticorpo (B-12) PE

sc-376594 PE
200 µg/ml
$343.00

ferritin heavy chain Anticorpo (B-12) Alexa Fluor® 488

sc-376594 AF488
200 µg/ml
$357.00

ferritin heavy chain Anticorpo (B-12) Alexa Fluor® 546

sc-376594 AF546
200 µg/ml
$357.00

ferritin heavy chain Anticorpo (B-12) Alexa Fluor® 594

sc-376594 AF594
200 µg/ml
$357.00

ferritin heavy chain Anticorpo (B-12) Alexa Fluor® 647

sc-376594 AF647
200 µg/ml
$357.00

ferritin heavy chain Anticorpo (B-12) Alexa Fluor® 680

sc-376594 AF680
200 µg/ml
$357.00

ferritin heavy chain Anticorpo (B-12) Alexa Fluor® 790

sc-376594 AF790
200 µg/ml
$357.00

Hi, do you have any updates on the validation of these Ab (conjugated) for flow cytometry (FC)? Are there any publications where these Ab were used for FC?

Asked by: OA___
Thank you for your question. It would be helpful if you could call 800-457-3801, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Service
Date published: 2022-07-13

Has this antibody been tested for Flow cytometry? At SCBT or any other published literature?

Asked by: sbagla
Thank you for your question. The unconjugated antibody has not yet been tested in that application. The conjugated primary antibody is recommended and warrantied for flow cytometry (FCM), however we are still gathering data to show on our website. Check back for updates!
Answered by: Technical Support
Date published: 2019-10-15

Did you teste this antibody for detection of mouse Fth? Although it is recomended, I would like to know if it was actually tested.

Asked by: dlcosta83
Thank you for your question. Ferritin heavy chain Antibody (B-12): sc-376594 is recommended for detection of ferritin heavy chain of mouse, rat and human origin by WB, IP, IF and ELISA and has been established for those species and applications in our labs. We base our recommendations on these tests. The antibody has also been used successfully with murine samples in a recent publication: PMID 30935115.
Answered by: Tech Support Europe
Date published: 2019-05-27

I wonder how was this antibody validated to not cross react with Ferritin light chain?, has it been tried to be plotted with ferritin composed out of only light chain (like Ferritin from spleen)? I would like to use it in sandwich ELISA

Asked by: Zaher
Thank you for your question. This monoclonal antibody is raised against an antigen that is specific to the ferritin heavy chain, and is not expected to cross-react with ferritin light chain. We have not tested this antibody in spleen.
Answered by: Technical Support
Date published: 2018-12-10

Hello, I would like to know if this antibody can be used to detect rat ferritin heavy chain? Thank you.

Asked by: Teddy Chen
Thank you for your question. We have not yet tested our monoclonal antibody, ferritin heavy chain (B-12): sc-376594, to confirm reactivity with rat samples. However, it is very likely that the antibody would react with rat ferritin heavy chain based on roughly 92% sequence identity shared between the immunogen and the published protein sequence for rat (accession: P19132). We are offering a free 10 µg sample of this antibody for a limited time. Please contact our Technical Service Department if you would like a sample to test the antibody in rat. Please call our European Support office toll-free at 00800 4573 8000, email europe@scbt.com, or contact us by live chat.
Answered by: Technical Support
Date published: 2017-03-02

What is the recommended secondary to use in Western Blot with this antibody?

Asked by: cjMara
Thank you for your question. We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent, Mouse IgG kappa BP HRP, sc-516102. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Service 11
Date published: 2017-01-19

Does this antibody (B12) cross-react with the ferritin light chain ?

Asked by: sv24
Thank you for your question. We do not expect this antibody, ferritin heavy chain Antibody (B-12): sc-376594, to cross-react with the ferritin light chain. The immunogen used to develop the antibody does not share significant sequence identity with the ferritin light chain protein. However, the exact epitope recognized by this monoclonal antibody has not been determined.
Answered by: Technical Support
Date published: 2016-12-17
  • y_2025, m_8, d_31, h_8CST
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Rated 5 out of 5 by from Strong bands!Very good antibody. Worked beautifully for westerns.
Date published: 2023-01-25
Rated 5 out of 5 by from Why there are two ferritin bands on your blotting?I got the same bands as your demo experiment, just curious why there are two bands for ferritin heavy chain
Date published: 2022-08-12
Rated 5 out of 5 by from Good stainingWorking perfect for IHC (1:100) in Sprague-Dawley rat spleen tissue (alcohol-fixed). No background.
Date published: 2022-07-14
Rated 5 out of 5 by from Good performance in WBWe are pleased to get clear band in WB with this antibody.
Date published: 2021-03-31
Rated 5 out of 5 by from WB, 1:200, KM12Working perfect for WB (1:200) in KM12 cell lysates (50 ug). No background, no unspecific bands.
Date published: 2017-10-11
Rated 4 out of 5 by from FTHThe FTH Antibody works very well for Western blot applications, showing strong and clear banding with minimal background noise present
Date published: 2017-07-31
Rated 4 out of 5 by from 有两条带这个抗体出现两个条带,我用的rat来源的细胞样品,一套在20kd左右,条带很浅,一条在35kd左右,条带深稀释倍数500。
Date published: 2017-07-17
Rated 5 out of 5 by from excellent for WBStrong, clear and right size band has been gotten by this specific antibody
Date published: 2017-04-11
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ferritin heavy chain Anticorpo (B-12) is rated 4.9 out of 5 by 14.
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