EphB1 Antibody (5F10A4): sc-130054

EphB1 Antibody (5F10A4) is a mouse monoclonal IgG1 kappa light chain antibody that detects EphB1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-EphB1 antibody (5F10A4) is available as a non-conjugated format. EphB1, a member of the Eph receptor family, plays a crucial role in mediating cell-cell interactions and is primarily located in the cell membrane, where EphB1 functions as a receptor for ephrin ligands. This localization enables EphB1 to participate in various signaling pathways that regulate processes such as neuronal development, angiogenesis, and tissue patterning. The interaction between EphB1 and ephrin-B1 ligands is essential for establishing boundaries between different cell types and facilitating communication during developmental processes. EphB1 receptor modulates synaptic plasticity, which is vital for learning and memory. With diverse roles in cellular signaling and development, EphB1 is a key player in both normal physiological processes and various pathological conditions, making anti-EphB1 antibody (5F10A4) an invaluable tool for researchers studying these critical biological functions.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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EphB1 Antibody (5F10A4) References:

1. EphB1 Suppression in Acute Myelogenous Leukemia: Regulating the DNA Damage Control System.  |  Kampen, KR., et al. 2015. Mol Cancer Res. 13: 982-92. PMID: 25944917
2. Paradoxes of the EphB1 receptor in malignant brain tumors.  |  Wei, W., et al. 2017. Cancer Cell Int. 17: 21. PMID: 28194092
3. EphB1 interaction with caveolin-1 in endothelial cells modulates caveolae biogenesis.  |  Tiruppathi, C., et al. 2020. Mol Biol Cell. 31: 1167-1182. PMID: 32238105
4. EphB1 promotes the differentiation and maturation of dendritic cells in non-small cell lung cancer.  |  Xie, Y., et al. 2024. Cancer Lett. 582: 216567. PMID: 38070822
5. EphB1 causes retinal damage through inflammatory pathways in the retina and retinal Müller cells.  |  Liu, L., et al. 2024. Mol Vis. 30: 167-174. PMID: 38601015
6. Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases.  |  Cheng, HJ. and Flanagan, JG. 1994. Cell. 79: 157-68. PMID: 7522971
7. Molecular cloning of a ligand for the EPH-related receptor protein-tyrosine kinase Htk.  |  Bennett, BD., et al. 1995. Proc Natl Acad Sci U S A. 92: 1866-70. PMID: 7534404
8. Identification of full-length and truncated forms of Ehk-3, a novel member of the Eph receptor tyrosine kinase family.  |  Valenzuela, DM., et al. 1995. Oncogene. 10: 1573-80. PMID: 7731712
9. Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system.  |  Ciossek, T., et al. 1995. Oncogene. 10: 97-108. PMID: 7824284
10. Ligands for the receptor tyrosine kinases hek and elk: isolation of cDNAs encoding a family of proteins.  |  Kozlosky, CJ., et al. 1995. Oncogene. 10: 299-306. PMID: 7838529
11. cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases.  |  Fox, GM., et al. 1995. Oncogene. 10: 897-905. PMID: 7898931
12. Molecular characterization of a family of ligands for eph-related tyrosine kinase receptors.  |  Beckmann, MP., et al. 1994. EMBO J. 13: 3757-62. PMID: 8070404

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EphB1 Antibody (5F10A4) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-EphB1 Antibody (5F10A4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EphB1 Antibody (5F10A4) Specifications

Alternate Product Name: EphB1

Product Clone Name: 5F10A4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 19-133

Epitope Target: EphB1

Epitope Species: human

Product Reactivity/Detection: EphB1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for EphB1 Antibody (5F10A4): N/A