CD71/TFRC/Transferrin Receptor Antibody (T56/14): sc-59111

CD71 Antibody (T56/14) is a mouse monoclonal IgG1 antibody that detects CD71 in human samples through western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). CD71, also known as the transferrin receptor (TFR), is a type II membrane glycoprotein that plays a crucial role in iron homeostasis by facilitating cellular uptake of iron through receptor-mediated endocytosis. CD71 exists as a disulfide-linked homodimer, binding to two molecules of transferrin, which is essential for transporting iron to cells, particularly in proliferating cells, reticulocytes, and erythroid precursors. CD71 expression is typically high in these cells, while resting leukocytes do not express CD71; however, CD71 is upregulated upon activation of lymphocytes, monocytes, and macrophages, highlighting CD71′s importance in immune responses and cellular proliferation. CD71 is present on brain endothelium and is critical for maintaining iron levels in the central nervous system. CD71′s presence on dividing cells underscores CD71′s significance in various physiological processes, including erythropoiesis and immune function, making CD71 a valuable target for research and therapeutic applications. Anti-CD71 antibody (T56/14) is an essential tool for studying iron metabolism and related disorders, including hereditary hemochromatosis type III, which is linked to mutations in transferrin receptor genes.

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CD71/TFRC/Transferrin Receptor Antibody (T56/14) References:

1. Enhanced expression of CD71, transferrin receptor, on immature reticulocytes in patients with paroxysmal nocturnal hemoglobinuria.  |  Sato, S., et al. 2010. Int J Lab Hematol. 32: e137-43. PMID: 19302232
2. Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target.  |  Magro, G., et al. 2011. Thyroid. 21: 267-77. PMID: 21323588
3. Interactions among secretory immunoglobulin A, CD71, and transglutaminase-2 affect permeability of intestinal epithelial cells to gliadin peptides.  |  Lebreton, C., et al. 2012. Gastroenterology. 143: 698-707.e4. PMID: 22750506
4. Strict tropism for CD71+/CD234+ human reticulocytes limits the zoonotic potential of Plasmodium cynomolgi.  |  Kosaisavee, V., et al. 2017. Blood. 130: 1357-1363. PMID: 28698207
5. Lower Abundance and Impaired Function of CD71+ Erythroid Cells in Inflammatory Bowel Disease Patients During Pregnancy.  |  Dunsmore, G., et al. 2019. J Crohns Colitis. 13: 230-244. PMID: 30272151
6. Novel lncRNA-IUR suppresses Bcr-Abl-induced tumorigenesis through regulation of STAT5-CD71 pathway.  |  Wang, X., et al. 2019. Mol Cancer. 18: 84. PMID: 30961617
7. Comparison between paramagnetic and CD71 magnetic activated cell sorting of fetal nucleated red blood cells from the maternal blood.  |  Nemescu, D., et al. 2020. J Clin Lab Anal. 34: e23420. PMID: 32588489
8. High activity and low toxicity of a novel CD71-targeting nanotherapeutic named The-0504 on preclinical models of several human aggressive tumors.  |  Falvo, E., et al. 2021. J Exp Clin Cancer Res. 40: 63. PMID: 33568214
9. The immunoregulatory function of peripheral blood CD71+ erythroid cells in systemic-onset juvenile idiopathic arthritis.  |  Kanemasa, H., et al. 2021. Sci Rep. 11: 14396. PMID: 34257378
10. Importance of CD71+ Erythrocyte Cell Levels in Prognosis in Patients With β-Thalassemia.  |  Görgülügil, GZ., et al. 2024. J Clin Lab Anal. 38: e25084. PMID: 38924171

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.