Cbl-3 Antibody (F-2): sc-390648

Cbl-3 Antibody (F-2) is a mouse monoclonal IgM antibody that detects Cbl-3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Cbl-3 antibody (F-2) is available as the non-conjugated form. Cbl-3, also known as RING finger protein 57, plays a crucial role in cellular signaling pathways by functioning as an E3 ubiquitin ligase, essential for the ubiquitination process that regulates protein degradation, thereby influencing various cellular processes such as cell cycle progression, apoptosis, and signal transduction. This regulation is particularly important in cancer, as aberrations in ubiquitination can lead to uncontrolled cell growth and tumorigenesis. Cbl-3 is closely related to other Cbl family proteins, including Cbl-b, and is expressed in various tissues, including hematopoietic cells, where Cbl-3 may interact with signaling proteins to modulate their activity. Cbl-3 gene is located on human chromosome 11q23, a region frequently implicated in leukemias due to involvement in chromosomal translocations and deletions. Cbl-3′s ability to interact with specific proteins and role in ubiquitination make Cbl-3 a significant target for research into cancer biology and therapeutic interventions.

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Cbl-3 Antibody (F-2) References:

1. cbl-3: a new mammalian cbl family protein.  |  Keane, MM., et al. 1999. Oncogene. 18: 3365-75. PMID: 10362357
2. The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.  |  Blake, TJ., et al. 1991. Oncogene. 6: 653-7. PMID: 2030914
3. The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein.  |  Langdon, WY., et al. 1989. J Virol. 63: 5420-4. PMID: 2585608
4. Identification of two murine loci homologous to the v-cbl oncogene.  |  Regnier, DC., et al. 1989. J Virol. 63: 3678-82. PMID: 2760978
5. v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.  |  Langdon, WY., et al. 1989. Proc Natl Acad Sci U S A. 86: 1168-72. PMID: 2784003
6. Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.  |  Keane, MM., et al. 1995. Oncogene. 10: 2367-77. PMID: 7784085
7. Formation of c-Cbl.phosphatidylinositol 3-kinase complexes on lymphocyte membranes by a p56lck-independent mechanism.  |  Hartley, D. and Corvera, S. 1996. J Biol Chem. 271: 21939-43. PMID: 8702998

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cbl-3 Antibody (F-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cbl-3 Antibody (F-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cbl-3 Antibody (F-2) Specifications

Alternate Product Name: Cbl-3

Product Clone Name: F-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 442-474

Epitope Target: Cbl-3

Epitope Species: human

Product Reactivity/Detection: Cbl-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cbl-3 Antibody (F-2): P: Blocking Peptide