NUDT4 Activators
NUDT4, short for Nucleoside Diphosphate-Linked Moiety X Motif 4, is an enzyme that plays a crucial role in nucleotide metabolism within cells. This enzyme is a member of the Nudix hydrolase family, which is known for its ability to hydrolyze various nucleoside diphosphate derivatives, contributing to the regulation of nucleotide pools and cellular homeostasis.The primary function of NUDT4 is to catalyze the hydrolysis of nucleoside diphosphates (NDPs), such as ADP (adenosine diphosphate) and GDP (guanosine diphosphate), to their corresponding nucleoside monophosphates (NMPs) and inorganic phosphate (Pi). This enzymatic activity is essential for maintaining the balance of nucleotide triphosphate (NTP) and nucleotide diphosphate (NDP) pools within the cell. By controlling the levels of these nucleotides, NUDT4 plays a critical role in cellular processes like DNA replication, RNA synthesis, and energy metabolism.
Additionally, NUDT4 is involved in maintaining mitochondrial function by influencing mitochondrial nucleotide pools. It has been suggested to participate in the regulation of mitochondrial DNA replication and repair, which are vital for the integrity of the mitochondrial genome.The expression and activity of NUDT4 are tightly regulated within the cell to ensure proper nucleotide balance and cellular function. Dysregulation of NUDT4 or mutations in its gene can lead to imbalances in nucleotide metabolism, which may contribute to various cellular dysfunctions and diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium | 7440-70-2 | sc-252536 | 5 g | $209.00 | ||
Calcium ions can activate NUDT4 enzymatic activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions may modulate NUDT4 activity as a cofactor. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN can serve as a substrate and activator of NUDT4. | ||||||
Guanosine-5′-monophosphate | 85-32-5 | sc-295032 sc-295032A sc-295032B | 1 g 2.5 g 5 g | $322.00 $622.00 $1051.00 | 5 | |
GMP can modulate NUDT4 enzymatic activity. | ||||||
Uridine 5′-monophosphate | 58-97-9 | sc-216044 | 1 g | $255.00 | ||
UMP may affect NUDT4 activity as a substrate. | ||||||
Inosine 5′-monophosphate disodium salt | 352195-40-5 | sc-215178 sc-215178A | 5 g 25 g | $42.00 $97.00 | ||
IMP may serve as a substrate and modulator of NUDT4. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ can interact with NUDT4 and potentially modulate its function. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP can affect NUDT4 activity as a substrate and activator. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP may modulate NUDT4 enzymatic activity. | ||||||
Guanosine 5′-diphosphate sodium salt hydrate (GDP) | 146-91-8 non-salt | sc-507402 | 10 mg | $645.00 | ||
GDP can potentially influence NUDT4 activity as a substrate. | ||||||