ZPR1 Antibody (D-3): sc-390125

ZPR1 Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects ZPR1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZPR1 (D-3) antibody plays a crucial role in understanding the dynamics of the epidermal growth factor receptor (EGFR) signaling pathway, as ZPR1 is a zinc finger-containing protein that interacts with the intracellular tyrosine kinase domain of EGFR. This interaction is significant because ZPR1 highlights the regulatory mechanisms of cell signaling; when epidermal growth factor binds to EGFR, EGFR activates the receptor′s intrinsic tyrosine kinase activity, which reduces ZPR1′s affinity for EGFR and promotes ZPR1′s translocation to the nucleus. The presence of the zinc finger motif in ZPR1 is essential for binding to EGFR, underscoring the importance of protein structure in mediating protein-protein interactions and cellular responses. Using anti-ZPR1 antibody (D-3) in research can provide valuable insights into the molecular mechanisms underlying cell growth and differentiation, as well as potential implications for therapeutic interventions in diseases associated with aberrant EGFR signaling.

The preferred ZPR1 antibody is ZPR1 Antibody (C-1): sc-398241.