ZNF276 Antibody (G-9): sc-373768
- ZNF276 Antibody (G-9) is a mouse monoclonal IgG1 κ ZNF276 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 371-399 within an internal region of ZNF276 of human origin
- ZNF276 Antibody (G-9) is recommended for detection of ZNF276 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-ZNF276 Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZNF276 Antibody (G-9) for WB and IHC(P) applications. These reagents are now offered in bundles with ZNF276 Antibody (G-9) (see ordering information below).
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ZNF276 Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZNF276 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ZNF276 (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZNF276 protein, consisting of 614 amino acids, features five C2H2-type zinc fingers and one zinc finger associated domain, which are critical for DNA binding and transcriptional regulation. ZNF276 plays a key role in regulating gene expression, influencing cellular processes such as proliferation and differentiation. Research has identified ZNF276 as a potential tumor suppressor in sporadic breast cancers due to loss of heterozygosity at its chromosomal location, highlighting ZNF276′s significance in cancer biology. The proximity of ZNF276 gene to the FANCA gene, which encodes a DNA repair protein, suggests ZNF276′s potential role in the progression of Fanconi anemia, a genetic disorder characterized by increased cancer risk. Two isoforms of ZNF276 arise from alternative splicing, contributing to functional diversity and regulatory mechanisms within the cell.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZNF276 Antibody (G-9) References:
- Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. | Wong, JC., et al. 2000. Genomics. 67: 273-83. PMID: 10936049
- Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. | Chung, HR., et al. 2002. EMBO Rep. 3: 1158-62. PMID: 12446571
- The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module. | Jauch, R., et al. 2003. Structure. 11: 1393-402. PMID: 14604529
- Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. | Wong, JCY., et al. 2003. J Hum Genet. 48: 668-671. PMID: 14605947
- Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. | Imami, K., et al. 2008. Anal Sci. 24: 161-6. PMID: 18187866
- Context-dependent DNA recognition code for C2H2 zinc-finger transcription factors. | Liu, J. and Stormo, GD. 2008. Bioinformatics. 24: 1850-7. PMID: 18586699
- Finger proteins and DNA-specific recognition: distinct patterns of conserved amino acids suggest different evolutionary modes. | Payre, F. and Vincent, A. 1988. FEBS Lett. 234: 245-50. PMID: 3292287
- The genetics of sporadic breast cancer. | Brenner, AJ. and Aldaz, CM. 1997. Prog Clin Biol Res. 396: 63-82. PMID: 9108590
- Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients. | Nakamura, A., et al. 1999. J Hum Genet. 44: 48-51. PMID: 9929978
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZNF276 Antibody (G-9) | sc-373768 | 200 µg/ml | $322.00 | |||
ZNF276 Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-529557 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZNF276 Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-522491 | 200 µg Ab, 40 µg BP | $361.00 | |||
ZNF276 Antibody (G-9) AC | sc-373768 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZNF276 Antibody (G-9) HRP | sc-373768 HRP | 200 µg/ml | $322.00 | |||
ZNF276 Antibody (G-9) FITC | sc-373768 FITC | 200 µg/ml | $336.00 | |||
ZNF276 Antibody (G-9) PE | sc-373768 PE | 200 µg/ml | $349.00 | |||
ZNF276 Antibody (G-9) Alexa Fluor® 488 | sc-373768 AF488 | 200 µg/ml | $364.00 | |||
ZNF276 Antibody (G-9) Alexa Fluor® 546 | sc-373768 AF546 | 200 µg/ml | $364.00 | |||
ZNF276 Antibody (G-9) Alexa Fluor® 594 | sc-373768 AF594 | 200 µg/ml | $364.00 | |||
ZNF276 Antibody (G-9) Alexa Fluor® 647 | sc-373768 AF647 | 200 µg/ml | $364.00 | |||
ZNF276 Antibody (G-9) Alexa Fluor® 680 | sc-373768 AF680 | 200 µg/ml | $364.00 | |||
ZNF276 Antibody (G-9) Alexa Fluor® 790 | sc-373768 AF790 | 200 µg/ml | $364.00 | |||
ZNF276 (G-9) Neutralizing Peptide | sc-373768 P | 100 µg/0.5 ml | $69.00 |