ZNF2 Antibody (C-2): sc-515483

ZNF2 Antibody (C-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects ZNF2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ZNF2 antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZNF2, also known as Zinc finger protein 2.2 or Zinc finger protein 661, is a crucial nuclear protein composed of 425 amino acids, featuring one KRAB domain and nine C2H2-type zinc fingers. ZNF2 plays a significant role in gene regulation through involvement in transcriptional activation and repression via DNA-binding capabilities. The presence of the KRAB domain allows ZNF2 to interact with KAP1 protein, which is essential for recruiting histone-modifying enzymes that alter chromatin structure, thereby influencing gene expression. ZNF2 is encoded on human chromosome 2, a region containing over 1,400 genes and implicated in various genetic disorders, including harlequin ichthyosis and lipid metabolic disorders. ZNF2′s ability to modulate transcriptional activity makes this protein a vital component in understanding cellular processes and potential therapeutic targets in diseases linked to gene regulation.

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ZNF2 Antibody (C-2) References:

1. The human KRAB/FPB containing zinc finger gene ZNF2 maps to chromosome 2q11.2.  |  Rocchi, M., et al. 1999. Cytogenet Cell Genet. 86: 305-6. PMID: 10575230
2. Expression, purification and partial characterization of the Krüppel-associated box (KRAB) from the human ZNF2 protein.  |  Rivieccio, V., et al. 2005. Protein Pept Lett. 12: 527-32. PMID: 16101389
3. Catalytic asymmetric mannich-type reactions activated by ZnF2 chiral diamine in aqueous media.  |  Hamada, T., et al. 2006. Chemistry. 12: 1205-15. PMID: 16267871
4. Structure/function of KRAB repression domains: structural properties of KRAB modules inferred from hydrodynamic, circular dichroism, and FTIR spectroscopic analyses.  |  Mannini, R., et al. 2006. Proteins. 62: 604-16. PMID: 16385564
5. The tandem zinc-finger region of human ZHX adopts a novel C2H2 zinc finger structure with a C-terminal extension.  |  Wienk, H., et al. 2009. Biochemistry. 48: 4431-9. PMID: 19348505
6. Members of the zinc finger protein gene family sharing a conserved N-terminal module.  |  Rosati, M., et al. 1991. Nucleic Acids Res. 19: 5661-7. PMID: 1945843
7. Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans.  |  Lin, X., et al. 2010. PLoS Genet. 6: e1000953. PMID: 20485569
8. The lncRNA RZE1 Controls Cryptococcal Morphological Transition.  |  Chacko, N., et al. 2015. PLoS Genet. 11: e1005692. PMID: 26588844
9. Trigonal-Bipyramidal Coordination in First Ammoniates of ZnF2: ZnF2(NH3)3 and ZnF2(NH3)2.  |  Richter, TM., et al. 2016. Inorg Chem. 55: 2488-98. PMID: 26894942
10. Transcription factor Znf2 coordinates with the chromatin remodeling SWI/SNF complex to regulate cryptococcal cellular differentiation.  |  Lin, J., et al. 2019. Commun Biol. 2: 412. PMID: 31754642
11. Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts.  |  Pham, T., et al. 2023. Infect Immun. 91: e0019823. PMID: 37338404
12. Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes.  |  Miller, J., et al. 1985. EMBO J. 4: 1609-14. PMID: 4040853

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZNF2 Antibody (C-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZNF2 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZNF2 Antibody (C-2) Specifications

Alternate Product Name: ZNF2

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 345-425

Epitope Target: ZNF2

Epitope Species: human

Product Reactivity/Detection: ZNF2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZNF2 Antibody (C-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin