ZKSCAN3 Antibody (A-10): sc-515285
- ZKSCAN3 Antibody (A-10) is a mouse monoclonal IgG1 κ ZKSCAN3 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 442-491 mapping near the C-terminus of ZKSCAN3 of human origin
- ZKSCAN3 Antibody (A-10) is recommended for detection of ZKSCAN3 of human origin by WB, IP, IF and ELISA
- Anti-ZKSCAN3 Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ZKSCAN3 Antibody (A-10) for WB applications. These reagents are now offered in bundles with ZKSCAN3 Antibody (A-10) (see ordering information below).
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ZKSCAN3 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZKSCAN3 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ZKSCAN3 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZKSCAN3, also known as Zinc finger protein with KRAB and SCAN domains 3, is a 583 amino acid protein that plays a crucial role in transcription regulation, particularly in cancer biology. As a member of the Krüppel C2H2-type zinc-finger protein family, ZKSCAN3 features seven C2H2-type zinc fingers, one KRAB domain, and one SCAN box domain, which are essential for DNA-binding capabilities and transcriptional regulatory functions. ZKSCAN3 has been implicated in colorectal cancer, with studies showing that overexpression is associated with invasive tumor types and that the chromosomal region encoding ZKSCAN3 is often amplified in colorectal cancer cases. Knockdown of ZKSCAN3 mRNA has been linked to impaired anchorage-independent growth and reduced tumor growth in colon cancer cell lines, highlighting potential as a therapeutic target.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ZKSCAN3 Antibody (A-10) References:
- Computer sequence analysis of human highly conserved zinc finger modules. | Petroni, D., et al. 1998. DNA Seq. 9: 163-9. PMID: 10520746
- The SCAN domain defines a large family of zinc finger transcription factors. | Sander, TL., et al. 2003. Gene. 310: 29-38. PMID: 12801630
- The identification and characterization of KRAB-domain-containing zinc finger proteins. | Constantinou-Deltas, CD., et al. 1992. Genomics. 12: 581-9. PMID: 1559709
- The SCAN domain family of zinc finger transcription factors. | Edelstein, LC. and Collins, T. 2005. Gene. 359: 1-17. PMID: 16139965
- Identification of five human novel genes associated with cell proliferation by cell-based screening from an expressed cDNA ORF library. | Ma, X., et al. 2007. Life Sci. 81: 1141-51. PMID: 17868742
- The previously undescribed ZKSCAN3 (ZNF306) is a novel 'driver' of colorectal cancer progression. | Yang, L., et al. 2008. Cancer Res. 68: 4321-30. PMID: 18519692
- Krüppel-associated boxes are potent transcriptional repression domains. | Margolin, JF., et al. 1994. Proc Natl Acad Sci U S A. 91: 4509-13. PMID: 8183939
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZKSCAN3 Antibody (A-10) | sc-515285 | 200 µg/ml | $322.00 | |||
ZKSCAN3 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-531329 | 200 µg Ab; 10 µg BP | $361.00 | |||
ZKSCAN3 Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-524993 | 200 µg Ab, 40 µg BP | $361.00 | |||
ZKSCAN3 Antibody (A-10): m-IgG1 BP-HRP Bundle | sc-544487 | 200 µg Ab; 20 µg BP | $361.00 | |||
ZKSCAN3 Antibody (A-10) AC | sc-515285 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ZKSCAN3 Antibody (A-10) HRP | sc-515285 HRP | 200 µg/ml | $322.00 | |||
ZKSCAN3 Antibody (A-10) FITC | sc-515285 FITC | 200 µg/ml | $336.00 | |||
ZKSCAN3 Antibody (A-10) PE | sc-515285 PE | 200 µg/ml | $349.00 | |||
ZKSCAN3 Antibody (A-10) Alexa Fluor® 488 | sc-515285 AF488 | 200 µg/ml | $364.00 | |||
ZKSCAN3 Antibody (A-10) Alexa Fluor® 546 | sc-515285 AF546 | 200 µg/ml | $364.00 | |||
ZKSCAN3 Antibody (A-10) Alexa Fluor® 594 | sc-515285 AF594 | 200 µg/ml | $364.00 | |||
ZKSCAN3 Antibody (A-10) Alexa Fluor® 647 | sc-515285 AF647 | 200 µg/ml | $364.00 | |||
ZKSCAN3 Antibody (A-10) Alexa Fluor® 680 | sc-515285 AF680 | 200 µg/ml | $364.00 | |||
ZKSCAN3 Antibody (A-10) Alexa Fluor® 790 | sc-515285 AF790 | 200 µg/ml | $364.00 |