ZDHHC8 Antibody (B-3): sc-374191

ZDHHC8 Antibody (B-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZDHHC8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZDHHC8 antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ZDHHC8, also known as KIAA1292, ZDHHCL1, or zinc finger protein 378, is a 765 amino acid multi-pass membrane protein primarily localized to cytoplasmic vesicle membranes. Such localization enables ZDHHC8 to function effectively as a putative palmitoyltransferase, catalyzing palmitoyl group transfer from palmitoyl-CoA to specific cysteine residues on target proteins, a process regulating protein interactions and membrane localization. ZDHHC8′s ability to modify proteins through palmitoylation plays a crucial role in glutamatergic transmission by influencing synaptic signaling and plasticity. Additionally, defects in ZDHHC8 have been linked to increased schizophrenia susceptibility, highlighting ZDHHC8′s potential role in neurodevelopmental disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ZDHHC8 Antibody (B-3) References:

1. Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia.  |  Mukai, J., et al. 2004. Nat Genet. 36: 725-31. PMID: 15184899
2. Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.  |  Chen, WY., et al. 2004. Hum Mol Genet. 13: 2991-5. PMID: 15489219
3. The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia.  |  Otani, K., et al. 2005. Neurosci Lett. 390: 166-70. PMID: 16150541
4. ZDHHC8 as a candidate gene for schizophrenia: analysis of a putative functional intronic marker in case-control and family-based association studies.  |  Faul, T., et al. 2005. BMC Psychiatry. 5: 35. PMID: 16225675
5. Analysis of ProDH, COMT and ZDHHC8 risk variants does not support individual or interactive effects on schizophrenia susceptibility.  |  Glaser, B., et al. 2006. Schizophr Res. 87: 21-7. PMID: 16860541
6. ZDHHC8 single nucleotide polymorphism rs175174 is not associated with psychiatric features of the 22q11 deletion syndrome or schizophrenia.  |  Demily, C., et al. 2007. Psychiatr Genet. 17: 311-2. PMID: 17728672
7. HTF9C gene of 22q11.21 region associates with schizophrenia having deficit-sustained attention.  |  Liu, YL., et al. 2007. Psychiatr Genet. 17: 333-8. PMID: 18075473
8. ZDHHC8 critically regulates seizure susceptibility in epilepsy.  |  Yang, Q., et al. 2018. Cell Death Dis. 9: 795. PMID: 30038264
9. Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability.  |  Strassburger, K., et al. 2019. PLoS One. 14: e0198149. PMID: 30735487
10. AMPKα1-mediated ZDHHC8 phosphorylation promotes the palmitoylation of SLC7A11 to facilitate ferroptosis resistance in glioblastoma.  |  Wang, Z., et al. 2024. Cancer Lett. 584: 216619. PMID: 38211651

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZDHHC8 Antibody (B-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ZDHHC8 Antibody (B-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZDHHC8 Antibody (B-3) Specifications

Alternate Product Name: ZDHHC8

Product Clone Name: B-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 471-503

Epitope Target: ZDHHC8

Epitope Species: human

Product Reactivity/Detection: ZDHHC8

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ZDHHC8 Antibody (B-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent