ZDHHC20 Antibody (A-4): sc-518217

ZDHHC20 Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects ZDHHC20 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ZDHHC20 antibody (A-4) is available in non-conjugated form. ZDHHC20, or zinc finger, DHHC-type containing 20, is a 365 amino acid multi-pass membrane protein that plays a crucial role in cellular signaling and membrane dynamics. ZDHHC20 functions primarily as a palmitoyltransferase, facilitating the addition of palmitate to cysteine residues on target proteins, which is essential for regulating protein localization, stability, and interactions. This post-translational modification is vital for the proper functioning of various signaling pathways, as it influences the membrane association of proteins and their subsequent activity. ZDHHC20 is subject to phosphorylation in response to DNA damage, which may alter its activity and interactions, highlighting its importance in cellular stress responses. The gene encoding ZDHHC20 is located on human chromosome 13, a region that is rich in genes associated with critical cellular functions, including tumor suppression and cell cycle regulation.

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ZDHHC20 Antibody (A-4) References:

1. The DHHC domain: a new highly conserved cysteine-rich motif.  |  Putilina, T., et al. 1999. Mol Cell Biochem. 195: 219-26. PMID: 10395086
2. The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase.  |  Roth, AF., et al. 2002. J Cell Biol. 159: 23-8. PMID: 12370247
3. Protein palmitoylation by a family of DHHC protein S-acyltransferases.  |  Mitchell, DA., et al. 2006. J Lipid Res. 47: 1118-27. PMID: 16582420
4. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins.  |  Ohno, Y., et al. 2006. Biochim Biophys Acta. 1761: 474-83. PMID: 16647879
5. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.  |  Matsuoka, S., et al. 2007. Science. 316: 1160-6. PMID: 17525332

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ZDHHC20 Antibody (A-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ZDHHC20 Antibody (A-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ZDHHC20 Antibody (A-4) Specifications

Alternate Product Name: ZDHHC20

Product Clone Name: A-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 87-108

Epitope Target: ZDHHC20

Epitope Species: human

Product Reactivity/Detection: ZDHHC20

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ZDHHC20 Antibody (A-4): N/A