ZDHHC20 Activators
ZDHHC20 Activators belong to a distinct chemical class that plays a crucial role in cellular processes related to protein modification and regulation. ZDHHC20, also known as DHHC20, is a member of the DHHC (Asp-His-His-Cys) family of palmitoyl acyltransferases. These enzymes are responsible for a post-translational modification known as palmitoylation, which involves the attachment of a fatty acid, specifically palmitate, to cysteine residues of target proteins. ZDHHC20 Activators are small molecules or compounds that enhance the activity of ZDHHC20, thereby influencing the palmitoylation process and subsequently impacting various cellular functions.
Palmitoylation, catalyzed by ZDHHC20 and regulated by its activators, is a reversible lipid modification that is known to modulate the localization, stability, and interactions of proteins within cells. This modification is vital for the proper functioning of numerous proteins involved in intracellular signaling, membrane trafficking, and synaptic transmission. ZDHHC20 Activators, by enhancing the enzymatic activity of ZDHHC20, can potentially fine-tune the palmitoylation status of target proteins, leading to downstream effects on cellular processes. While the specific molecular mechanisms underlying the activation of ZDHHC20 by these compounds may vary, their ability to modulate protein palmitoylation represents a novel avenue for understanding and potentially manipulating cellular functions.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
S1P acts on sphingosine-1-phosphate receptors to activate downstream signaling pathways including AKT, which can enhance ZDHHC20 palmitoylation activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, activating PKA, which can phosphorylate proteins including those that associate with ZDHHC20, potentially affecting its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which can lead to phosphorylation of substrates that may interact with ZDHHC20, possibly enhancing its palmitoyltransferase function. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can modulate calcium-dependent protein kinases, potentially influencing ZDHHC20 activity through downstream effects. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP acts as a cAMP analog, activating PKA and thus may enhance the activity of ZDHHC20 through phosphorylation of associated proteins. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 is a sphingosine 1-phosphate receptor modulator that can activate signaling pathways affecting ZDHHC20's function in protein palmitoylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases PP1 and PP2A, which can increase phosphorylation levels of proteins that might regulate ZDHHC20 activity indirectly. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as a calcium ionophore, elevating intracellular calcium levels and could indirectly enhance ZDHHC20 activity through calcium-dependent signaling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), elevating cytosolic calcium levels, potentially affecting ZDHHC20 activity. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 inhibits PKA, which can lead to compensatory activation of alternative pathways that might enhance ZDHHC20's function indirectly. | ||||||