YAP Antibody (G-6): sc-376830
- YAP Antibody (G-6) is a mouse monoclonal IgG1 κ YAP antibody, cited in 80 publications, provided at 200 µg/ml
- raised against amino acids 206-330 mapping near the C-terminus of YAP of human origin
- YAP Antibody (G-6) is recommended for detection of YAP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-YAP Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-376830 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for YAP Antibody (G-6) for WB and IHC(P) applications. These reagents are now offered in bundles with YAP Antibody (G-6) (see ordering information below).
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SEE ALSO...
YAP Antibody (G-6) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Yes-associated protein (YAP), also known as YAP1, across multiple species including mouse, rat, and human. anti-YAP antibody (G-6) targets an epitope mapping to amino acids 206-330 near the C-terminus of human YAP, ensuring precise and reliable binding in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). YAP is a crucial component of the Hippo signaling pathway and functions as a transcriptional co-activator, playing a vital role in regulating cell proliferation, apoptosis, and organ size. Structurally, YAP contains multiple WW domains and a TEAD-binding domain, which facilitate interactions with other proteins and transcription factors, thereby modulating gene expression and maintaining cellular homeostasis. The structural integrity of YAP is essential for linking extracellular signals to nuclear responses, making YAP pivotal in processes such as tissue regeneration and tumorigenesis. By interacting with 14-3-3 proteins through phosphorylated serine residue (Ser112), YAP′s localization and activity within the cell are tightly regulated, allowing shuttling between the cytoplasm and nucleus in response to various cellular cues. Additionally, YAP shares significant homology with TAZ (transcriptional co-activator with PDZ-binding motif), another key player in the Hippo pathway, highlighting YAP′s importance in complex cellular signaling networks. Expressed abundantly in tissues such as the lung, placenta, prostate, ovary, and testis, YAP (G-6) antibody is an indispensable tool for researchers aiming to explore the structural and functional dynamics of YAP in both normal physiology and disease states. YAP monoclonal antibody (G-6) recognizes YAP across different species and in multiple assay formats, making this antibody essential for studies investigating the diverse biological roles and regulatory mechanisms involving YAP.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
YAP Antibody (G-6) | sc-376830 | 200 µg/ml | $322.00 | |||
YAP Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-527550 | 200 µg Ab; 10 µg BP | $361.00 | |||
YAP Antibody (G-6): m-IgG1 BP-HRP Bundle | sc-532923 | 200 µg Ab; 20 µg BP | $361.00 | |||
YAP Antibody (G-6) X | sc-376830 X | 200 µg/0.1 ml | $322.00 | |||
YAP Antibody (G-6) AC | sc-376830 AC | 500 µg/ml, 25% agarose | $424.00 | |||
YAP Antibody (G-6) HRP | sc-376830 HRP | 200 µg/ml | $322.00 | |||
YAP Antibody (G-6) FITC | sc-376830 FITC | 200 µg/ml | $336.00 | |||
YAP Antibody (G-6) PE | sc-376830 PE | 200 µg/ml | $349.00 | |||
YAP Antibody (G-6) Alexa Fluor® 488 | sc-376830 AF488 | 200 µg/ml | $364.00 | |||
YAP Antibody (G-6) Alexa Fluor® 546 | sc-376830 AF546 | 200 µg/ml | $364.00 | |||
YAP Antibody (G-6) Alexa Fluor® 594 | sc-376830 AF594 | 200 µg/ml | $364.00 | |||
YAP Antibody (G-6) Alexa Fluor® 647 | sc-376830 AF647 | 200 µg/ml | $364.00 | |||
YAP Antibody (G-6) Alexa Fluor® 680 | sc-376830 AF680 | 200 µg/ml | $364.00 | |||
YAP Antibody (G-6) Alexa Fluor® 790 | sc-376830 AF790 | 200 µg/ml | $364.00 |