XylT-II Antibody (G-1): sc-374134

XylT-II Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects XylT-II protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XylT-II (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. XylT-II protein, also known as UDP-D-xylose:proteoglycan core protein β-D-xylosyltransferase 2, plays a crucial role in glycosaminoglycan biosynthesis, essential components of proteoglycans that contribute to extracellular matrix structural integrity and function. XylT-II protein is primarily located in the endoplasmic reticulum and Golgi apparatus, where UDP-xylose transfer to specific serine residues on target proteins occurs, a process vital for proper glycosaminoglycan chain formation. XylT-II protein activity is particularly important in tissues such as kidney and pancreas, where high expression occurs, and dysregulation can lead to various pathological conditions. Anti-XylT-II antibody (G-1) serves as an invaluable tool for researchers studying glycosylation roles in cellular processes and disease mechanisms.

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XylT-II Antibody (G-1) References:

1. Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity.  |  Götting, C., et al. 2004. J Biol Chem. 279: 42566-73. PMID: 15294915
2. Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity.  |  Müller, S., et al. 2005. Biochem J. 386: 227-36. PMID: 15461586
3. Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency.  |  Schöttler, M., et al. 2005. Clin Biochem. 38: 486-8. PMID: 15820781
4. Xylosyltransferase I acceptor properties of fibroblast growth factor and its fragment bFGF (1-24).  |  Kuhn, J., et al. 2005. Biochem Biophys Res Commun. 333: 156-66. PMID: 15936726
5. Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis.  |  Götting, C., et al. 2005. J Mol Med (Berl). 83: 984-92. PMID: 16133423
6. Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy.  |  Schön, S., et al. 2005. Kidney Int. 68: 1483-90. PMID: 16164625
7. Human xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme.  |  Müller, S., et al. 2006. Biochem J. 394: 163-71. PMID: 16225459
8. Mutational and functional analyses of xylosyltransferases and their implication in osteoarthritis.  |  Schön, S., et al. 2006. Osteoarthritis Cartilage. 14: 442-8. PMID: 16376579
9. Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II.  |  Schön, S., et al. 2006. J Biol Chem. 281: 14224-31. PMID: 16569644
10. Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course.  |  Schön, S., et al. 2006. J Med Genet. 43: 745-9. PMID: 16571645
11. The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a risk factor for diabetic nephropathy in type 1 diabetes.  |  Schön, S., et al. 2006. Diabetes Care. 29: 2295-9. PMID: 17003309
12. First in-gel detection and purification of human xylosyltransferase II.  |  Casanova, JC., et al. 2009. Biochem Biophys Res Commun. 379: 243-8. PMID: 19100717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-XylT-II Antibody (G-1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-XylT-II Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

XylT-II Antibody (G-1) Specifications

Alternate Product Name: XylT-II

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 31-110

Epitope Target: XylT-II

Epitope Species: human

Product Reactivity/Detection: XylT-II

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for XylT-II Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin