XRCC2 Antibody (F-4): sc-365854

XRCC2 Antibody (F-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects XRCC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XRCC2 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. XRCC2 plays a crucial role in the repair of DNA double-strand breaks through homologous recombination, a vital process for maintaining genomic stability during cell division. XRCC2 is essential for the proper functioning of the DNA repair machinery, facilitating the exchange of genetic material between sister chromatids, thereby ensuring accurate repair and preventing mutations that could lead to cancer. Additionally, XRCC2 interacts with other key proteins involved in DNA repair, such as Rad51, which is critical for the homologous recombination repair pathway. Deficiencies in XRCC2 can lead to increased sensitivity to DNA-damaging agents and contribute to genomic instability, underscoring its importance in cellular health and the prevention of tumorigenesis.

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XRCC2 Antibody (F-4) References:

1. DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity.  |  Modesti, M., et al. 1999. EMBO J. 18: 2008-18. PMID: 10202163
2. The role of homologous recombination processes in the repair of severe forms of DNA damage in mammalian cells.  |  Thacker, J. 1999. Biochimie. 81: 77-85. PMID: 10214913
3. A surfeit of RAD51-like genes?  |  Thacker, J. 1999. Trends Genet. 15: 166-8. PMID: 10322480
4. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination.  |  Johnson, RD., et al. 1999. Nature. 401: 397-9. PMID: 10517641
5. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.  |  Pierce, AJ., et al. 1999. Genes Dev. 13: 2633-8. PMID: 10541549
6. A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p.  |  Moshous, D., et al. 2000. Hum Mol Genet. 9: 583-8. PMID: 10699181
7. A naturally occurring genetic variant of human XRCC2 (R188H) confers increased resistance to cisplatin-induced DNA damage.  |  Danoy, P., et al. 2007. Biochem Biophys Res Commun. 352: 763-8. PMID: 17141189
8. shRNA-mediated XRCC2 gene knockdown efficiently sensitizes colon tumor cells to X-ray irradiation in vitro and in vivo.  |  Wang, Q., et al. 2014. Int J Mol Sci. 15: 2157-71. PMID: 24481064
9. XRCC2 rs3218536 polymorphism decreases the sensitivity of colorectal cancer cells to poly(ADP-ribose) polymerase 1 inhibitor.  |  Xu, K., et al. 2014. Oncol Lett. 8: 1222-1228. PMID: 25120693
10. XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.  |  Zhang, YX., et al. 2019. Clin Genet. 95: 442-443. PMID: 30489636
11. XRCC1 protein interacts with one of two distinct forms of DNA ligase III.  |  Nash, RA., et al. 1997. Biochemistry. 36: 5207-11. PMID: 9136882
12. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.  |  Liu, N., et al. 1998. Mol Cell. 1: 783-93. PMID: 9660962

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-XRCC2 Antibody (F-4) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-XRCC2 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

XRCC2 Antibody (F-4) Specifications

Alternate Product Name: XRCC2

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 6-33

Epitope Target: XRCC2

Epitope Species: human

Product Reactivity/Detection: XRCC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for XRCC2 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin