XAB1 Antibody (A-10): sc-365866

XAB1 Antibody (A-10) is a mouse monoclonal IgG1 antibody that detects XAB1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). XAB1, also known as XPA binding protein 1, MBDIN, NTPBP, ATPBD1A, or HUSSY-23, is a 374 amino acid cytoplasmic protein that plays a crucial role in protein synthesis and assembly. XAB1 is expressed ubiquitously, with the highest levels found in the testis, and binds to RNA polymerase II-associated proteins RPAP1-3 and XPA, a key player in DNA repair mechanisms. This interaction facilitates RNA polymerase II involvement in both protein complex formation and protein chaperoning, highlighting XAB1′s importance in maintaining cellular function and integrity. Additionally, XAB1′s structure features a cluster of acidic amino acids in its C-terminal region and sequences reminiscent of GTP-binding proteins in its N-terminal region, suggesting potential GTPase activity that may further influence its role in cellular processes. Anti-XAB1 antibody (A-10) is an essential tool for researchers investigating the dynamics of protein synthesis and the intricate mechanisms of DNA repair in human cells.

The preferred XAB1 antibody is XAB1 Antibody (B-4): sc-365865.