X11γ Antibody (H-6): sc-514074
- X11γ Antibody (H-6) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 74-99 within an internal region of X11γ of human origin
- recommended for detection of X11γ of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for X11γ Antibody (H-6). This work is in progress.
X11γ Antibody (H-6) is a mouse monoclonal IgM antibody that detects X11γ in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11γ, a member of the X11 family of proteins, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11γ is primarily located in the cytoplasm and interacts with β-APP via its phosphotyrosine binding (PTB) domain, effectively modulating the internalization and secretion of β-APP. This interaction is mediated through the YENPTY motif of β-APP, which is essential for its endocytosis and subsequent processing. By influencing these pathways, X11γ not only helps maintain cellular homeostasis but also has implications for the pathogenesis of neurodegenerative diseases, making X11γ a vital target for research. Anti-X11γ antibody (H-6) serves as an invaluable tool for scientists studying the molecular mechanisms underlying Alzheimer′s disease and related disorders, providing insights into the complex interactions that govern protein processing and cellular signaling.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11γ Antibody (H-6) | sc-514074 | 200 µg/ml | $322.00 | |||
X11γ (H-6) Neutralizing Peptide | sc-514074 P | 100 µg/0.5 ml | $69.00 |