X11β Antibody (C-7): sc-376566
- X11β Antibody (C-7) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-31 at the N-terminus of X11β of human origin
- recommended for detection of X11β of human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for X11β Antibody (C-7) for WB applications. This reagent is now offered in a bundle with X11β Antibody (C-7) (see ordering information below).
X11β Antibody (C-7) is a mouse monoclonal IgG3 antibody that detects X11β in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). X11β, a member of the X11 family of proteins, plays a crucial role in the regulation of β-Amyloid precursor protein (β-APP) processing, which is significant in the context of Alzheimer′s disease. X11β is primarily located in the cytoplasm and interacts with β-APP via its phosphotyrosine binding (PTB) domain, specifically binding to the YENPTY motif. This interaction modulates the internalization and secretion of β-APP, thereby influencing the accumulation of amyloid plaques that are characteristic of Alzheimer′s pathology. The presence of multiple splice variants of X11, including X11α (Mint 1), X11β (Mint 2), and X11γ (Mint 3), further highlights the complexity of regulatory functions and potential implications in neurodegenerative diseases. anti-X11β antibody (C-7) serves as an essential tool for researchers exploring the intricate mechanisms of β-APP processing and its association with Alzheimer′s disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
X11β Antibody (C-7) | sc-376566 | 200 µg/ml | $322.00 | |||
X11β Antibody (C-7): m-IgG3 BP-HRP Bundle | sc-550458 | 200 µg Ab; 40 µg BP | $361.00 | |||
X11β (C-7) Neutralizing Peptide | sc-376566 P | 100 µg/0.5 ml | $69.00 |