WWOX Antibody (D-9): sc-390175
- WWOX Antibody (D-9) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-126 mapping at the N-terminus of WWOX of human origin
- recommended for detection of WWOX of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for WWOX Antibody (D-9) for WB applications. These reagents are now offered in bundles with WWOX Antibody (D-9) (see ordering information below).
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SEE ALSO...
WWOX Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects WWOX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WWOX, or WW domain containing oxidoreductase, is a candidate tumor suppressor that plays a crucial role in cellular processes, including apoptosis and sex-steroid metabolism regulation, due to its unique structure comprising two WW domains that facilitate protein-protein interactions and a short chain dehydrogenase (SDR) domain. WWOX′s importance lies in modulating pathways associated with cancer, as alterations in WWOX gene have been linked to esophageal squamous cell carcinogenesis and tumorigenicity of breast cancer cell lines such as MDA-MB-435 and T47D. The murine homolog WOX1 is localized in mitochondria, where WOX1 contains a mitochondrial targeting sequence within the SDR domain, underscoring WOX1′s potential role in mitochondrial function and cellular energy metabolism. WWOX interacts with c-Jun N-terminal kinase 1 (JNK1), which can sequester WWOX and influence apoptosis, highlighting WWOX′s significance in cancer biology and therapeutic targeting.
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WWOX Antibody (D-9) References:
- Role of WWOX and NF-κB in lung cancer progression. | Chen, SJ., et al. 2013. Transl Respir Med. 1: 15. PMID: 27234396
- Decreased WWOX expression promotes angiogenesis in osteosarcoma. | Wen, J., et al. 2017. Oncotarget. 8: 60917-60932. PMID: 28977834
- Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events. | Huang, SS. and Chang, NS. 2018. Exp Biol Med (Maywood). 243: 137-147. PMID: 29310447
- Decoding the link between WWOX and p53 in aggressive breast cancer. | Abdeen, SK. and Aqeilan, RI. 2019. Cell Cycle. 18: 1177-1186. PMID: 31075076
- Molecular Functions of WWOX Potentially Involved in Cancer Development. | Taouis, K., et al. 2021. Cells. 10: PMID: 33946771
- WWOX-rs13338697 genotype predicts therapeutic efficacy of ADI-PEG 20 for patients with advanced hepatocellular carcinoma. | Chu, YD., et al. 2022. Front Oncol. 12: 996820. PMID: 36530994
- WWOX activates autophagy to alleviate lipopolysaccharide-induced acute lung injury by regulating mTOR. | Wang, C., et al. 2023. Int Immunopharmacol. 115: 109671. PMID: 36621327
- WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12. | Hussain, T., et al. 2023. Prog Neurobiol. 223: 102425. PMID: 36828035
- Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis. | Shin, MJ., et al. 2023. Int J Mol Sci. 25: PMID: 38203337
- Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection. | Bidany-Mizrahi, T., et al. 2024. Cell Death Discov. 10: 145. PMID: 38499540
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WWOX Antibody (D-9) | sc-390175 | 200 µg/ml | $322.00 | |||
WWOX Antibody (D-9): m-IgG Fc BP-HRP Bundle | sc-540767 | 200 µg Ab; 10 µg BP | $361.00 | |||
WWOX Antibody (D-9): m-IgG1 BP-HRP Bundle | sc-542359 | 200 µg Ab; 20 µg BP | $361.00 |