Wnt-2b Antibody (C-2): sc-166502
- Wnt-2b Antibody (C-2) is a mouse monoclonal IgG2b κ Wnt-2b antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 263-301 within an internal region of Wnt-2b of human origin
- Wnt-2b Antibody (C-2) is recommended for detection of Wnt-2b of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-Wnt-2b Antibody (C-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Wnt-2b Antibody (C-2) for WB applications. These reagents are now offered in bundles with Wnt-2b Antibody (C-2) (see ordering information below).
Wnt-2b Antibody (C-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects Wnt-2b protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Wnt-2b antibody (C-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Wnt-2b, also known as WNT13 or XWNT2, is a 391 amino acid secreted protein that plays a crucial role in cell signaling and development. Wnt-2b belongs to the Wnt family of proto-oncogenes, which are essential for various biological processes, including cell fate determination and embryogenesis. Wnt-2b functions as a ligand for transmembrane receptor proteins, initiating signaling pathways that influence tissue differentiation and development. Wnt-2b expression appears in various cancer cell lines, indicating potential involvement in tumorigenesis and making Wnt-2b a significant target for cancer research. Wnt-2b presence in both adult and fetal tissues, through two isoforms, highlights Wnt-2b importance in developmental biology and cancer progression studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Wnt-2b Antibody (C-2) References:
- Alternative splicing of the WNT-2B/WNT-13 gene. | Katoh, M., et al. 2000. Biochem Biophys Res Commun. 275: 209-16. PMID: 10944466
- Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. | Ricken, A., et al. 2002. Endocrinology. 143: 2741-9. PMID: 12072409
- Cloning and developmental expression in Xenopus laevis of seven additional members of the Wnt family. | Wolda, SL. and Moon, RT. 1992. Oncogene. 7: 1941-7. PMID: 1408135
- Molecular evolution of Wnt2b orthologs. | Katoh, M. 2005. Int J Oncol. 26: 1135-9. PMID: 15754012
- WNT2B: comparative integromics and clinical applications (Review). | Katoh, M. 2005. Int J Mol Med. 16: 1103-8. PMID: 16273293
- Mitochondrial and nuclear forms of Wnt13 are generated via alternative promoters, alternative RNA splicing, and alternative translation start sites. | Struewing, IT., et al. 2006. J Biol Chem. 281: 7282-93. PMID: 16407296
- Mesodermal Wnt2b signalling positively regulates liver specification. | Ober, EA., et al. 2006. Nature. 442: 688-91. PMID: 16799568
- Wnt family proteins are secreted and associated with the cell surface. | Smolich, BD., et al. 1993. Mol Biol Cell. 4: 1267-75. PMID: 8167409
- Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. | Katoh, M., et al. 1996. Oncogene. 13: 873-6. PMID: 8761309
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wnt-2b Antibody (C-2) | sc-166502 | 200 µg/ml | $322.00 | |||
Wnt-2b Antibody (C-2): m-IgGκ BP-HRP Bundle | sc-521633 | 200 µg Ab, 40 µg BP | $361.00 | |||
Wnt-2b Antibody (C-2): m-IgG2b BP-HRP Bundle | sc-548943 | 200 µg Ab; 10 µg BP | $361.00 | |||
Wnt-2b Antibody (C-2) AC | sc-166502 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Wnt-2b Antibody (C-2) HRP | sc-166502 HRP | 200 µg/ml | $322.00 | |||
Wnt-2b Antibody (C-2) FITC | sc-166502 FITC | 200 µg/ml | $336.00 | |||
Wnt-2b Antibody (C-2) PE | sc-166502 PE | 200 µg/ml | $349.00 | |||
Wnt-2b Antibody (C-2) Alexa Fluor® 488 | sc-166502 AF488 | 200 µg/ml | $364.00 | |||
Wnt-2b Antibody (C-2) Alexa Fluor® 546 | sc-166502 AF546 | 200 µg/ml | $364.00 | |||
Wnt-2b Antibody (C-2) Alexa Fluor® 594 | sc-166502 AF594 | 200 µg/ml | $364.00 | |||
Wnt-2b Antibody (C-2) Alexa Fluor® 647 | sc-166502 AF647 | 200 µg/ml | $364.00 | |||
Wnt-2b Antibody (C-2) Alexa Fluor® 680 | sc-166502 AF680 | 200 µg/ml | $364.00 | |||
Wnt-2b Antibody (C-2) Alexa Fluor® 790 | sc-166502 AF790 | 200 µg/ml | $364.00 |