WHIP Antibody (G-2): sc-377402
- WHIP Antibody (G-2) is a mouse monoclonal IgG1 κ WHIP antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 91-129 near the N-terminus of WHIP of human origin
- WHIP Antibody (G-2) is recommended for detection of WHIP of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-WHIP Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-377402 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for WHIP Antibody (G-2) for WB and IHC(P) applications. These reagents are now offered in bundles with WHIP Antibody (G-2) (see ordering information below).
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WHIP Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects WHIP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). WHIP (G-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. WHIP protein, also known as WRNIP1 (Werner helicase-interacting protein 1), plays a crucial role in DNA synthesis regulation and is localized in the nucleus, where WRNIP1 is involved in the modulation of initiation events during DNA polymerase-mediated DNA synthesis. This localization is significant as WRNIP1 interacts with DNA replication machinery and responds to DNA damage or stalled replication forks through ATPase activity. WHIP is found in granular structures within the nucleus and interacts with the N-terminal domain of WRN, the protein product of the gene associated with Werner′s syndrome, a disorder characterized by premature aging and increased cancer risk. The close association between WHIP and WRN suggests WHIP may contribute to the aging process and the pathogenesis of Werner′s syndrome. Additionally, WHIP is produced in four isoforms due to alternative splicing, which may further diversify functional roles in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
WHIP Antibody (G-2) References:
- A novel protein interacts with the Werner's syndrome gene product physically and functionally. | Kawabe Yi, ., et al. 2001. J Biol Chem. 276: 20364-9. PMID: 11301316
- Unwinding the molecular basis of the Werner syndrome. | Shen, J. and Loeb, LA. 2001. Mech Ageing Dev. 122: 921-44. PMID: 11348659
- The Werner syndrome protein at the crossroads of DNA repair and apoptosis. | Comai, L. and Li, B. 2004. Mech Ageing Dev. 125: 521-8. PMID: 15336909
- Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta. | Tsurimoto, T., et al. 2005. Genes Cells. 10: 13-22. PMID: 15670210
- Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell. | Kawabe, Y., et al. 2006. DNA Repair (Amst). 5: 816-28. PMID: 16769258
- Functional relationships between Rad18 and WRNIP1 in vertebrate cells. | Yoshimura, A., et al. 2006. Biol Pharm Bull. 29: 2192-6. PMID: 17077513
- Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain. | Bish, RA. and Myers, MP. 2007. J Biol Chem. 282: 23184-93. PMID: 17550899
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WHIP Antibody (G-2) | sc-377402 | 200 µg/ml | $322.00 | |||
WHIP Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-530022 | 200 µg Ab; 10 µg BP | $361.00 | |||
WHIP Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-523315 | 200 µg Ab, 40 µg BP | $361.00 | |||
WHIP Antibody (G-2) X | sc-377402 X | 200 µg/0.1 ml | $322.00 | |||
WHIP Antibody (G-2) AC | sc-377402 AC | 500 µg/ml, 25% agarose | $424.00 | |||
WHIP Antibody (G-2) HRP | sc-377402 HRP | 200 µg/ml | $322.00 | |||
WHIP Antibody (G-2) FITC | sc-377402 FITC | 200 µg/ml | $336.00 | |||
WHIP Antibody (G-2) PE | sc-377402 PE | 200 µg/ml | $349.00 | |||
WHIP Antibody (G-2) Alexa Fluor® 488 | sc-377402 AF488 | 200 µg/ml | $364.00 | |||
WHIP Antibody (G-2) Alexa Fluor® 546 | sc-377402 AF546 | 200 µg/ml | $364.00 | |||
WHIP Antibody (G-2) Alexa Fluor® 594 | sc-377402 AF594 | 200 µg/ml | $364.00 | |||
WHIP Antibody (G-2) Alexa Fluor® 647 | sc-377402 AF647 | 200 µg/ml | $364.00 | |||
WHIP Antibody (G-2) Alexa Fluor® 680 | sc-377402 AF680 | 200 µg/ml | $364.00 | |||
WHIP Antibody (G-2) Alexa Fluor® 790 | sc-377402 AF790 | 200 µg/ml | $364.00 | |||
WHIP (G-2) Neutralizing Peptide | sc-377402 P | 100 µg/0.5 ml | $69.00 |