WDR61 Antibody (WW-5): sc-100897

WDR61 Antibody (WW-5) is a mouse monoclonal IgG2b kappa light chain antibody that detects WDR61 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR61 antibody (WW-5) is available as the non-conjugated format. WDR61, also known as SKI8 or REC14, is a 305 amino acid protein characterized by the presence of seven WD-repeats, which are structural motifs that typically form a distinctive propeller-like tertiary structure. This unique structure facilitates WDR61′s role in various cellular processes, including RNA surveillance and transcriptional regulation, by serving as a subunit of the human Ski and PAF complexes. These complexes are integral to the regulation of gene expression and maintenance of cellular homeostasis, highlighting WDR61′s importance in ensuring proper cellular function. WDR61′s ability to interact with other proteins involved in RNA processing and signal transduction further underscores its significance in cellular regulatory mechanisms.

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WDR61 Antibody (WW-5) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.  |  Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
3. The human PAF complex coordinates transcription with events downstream of RNA synthesis.  |  Zhu, B., et al. 2005. Genes Dev. 19: 1668-73. PMID: 16024656
4. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.  |  Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
6. Cyclic tensile strain upon human mesenchymal stem cells in 2D and 3D culture differentially influences CCNL2, WDR61 and BAHCC1 gene expression levels.  |  Rathbone, SR., et al. 2012. J Mech Behav Biomed Mater. 11: 82-91. PMID: 22658157
7. Association Between Wnt Target Genes and Cortical Volumes in Alzheimer's Disease.  |  Dong, L., et al. 2023. J Mol Neurosci. 73: 1010-1016. PMID: 38135866
8. WDR61 ablation triggers R-loop accumulation and suppresses breast cancer progression.  |  Hou, Y., et al. 2024. FEBS J. 291: 3417-3431. PMID: 38708718
9. WD-repeat containing protein-61 regulates endometrial epithelial cell adhesion indicating an important role in receptivity.  |  Downing, P., et al. 2024. Mol Hum Reprod. 30: PMID: 39531333
10. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
11. Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.  |  Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
12. Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.  |  Garcia-Higuera, I., et al. 1998. J Biol Chem. 273: 9041-9. PMID: 9535892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDR61 Antibody (WW-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-WDR61 Antibody (WW-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDR61 Antibody (WW-5) Specifications

Alternate Product Name: WDR61

Product Clone Name: WW-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-146

Epitope Target: WDR61

Epitope Species: human

Product Reactivity/Detection: WDR61

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for WDR61 Antibody (WW-5): N/A