WDR5 Antibody (SF-14): sc-100895
- WDR5 Antibody (SF-14) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 100 µg/ml
- raised against recombinant WDR5 of human origin
- recommended for detection of WDR5 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WDR5 Antibody (SF-14). This work is in progress.
WDR5 Antibody (SF-14) is a mouse monoclonal IgG2b antibody that detects WDR5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WDR5, also known as BMP-2-induced gene 3 kb or BIG-3, is a crucial component of the Trithorax (TRX) histone methyltransferase complexes, which are vital for regulating gene expression during vertebrate development. WDR5 is primarily located in the nucleus, where WDR5 plays a significant role in the activation of Hox genes and the global trimethylation of histone H3 at lysine 4 (H3K4me3), a modification associated with active transcription. The presence of WDR5 in osteoblasts, chondrocytes, osteocytes, and marrow stromal cells highlights WDR5′s importance in bone development and differentiation, particularly in accelerating osteoblast differentiation through seven WD-repeats, which facilitate protein-protein interactions essential for function. Anti-WDR5 antibody (SF-14) is an invaluable tool for researchers studying epigenetic regulation and developmental biology, providing insights into the mechanisms underlying gene expression and cellular differentiation.
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WDR5 Antibody (SF-14) References:
- A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. | Yu, X., et al. 2021. Sci Transl Med. 13: eabj1578. PMID: 34586829
- GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation. | Wei, S., et al. 2021. mBio. 12: e0343121. PMID: 34933446
- The lncRNA BDNF-AS/WDR5/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination. | Huang, G., et al. 2022. Int J Biol Sci. 18: 1415-1433. PMID: 35280682
- HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program. | Huang, M., et al. 2022. Cancer Commun (Lond). 42: 447-470. PMID: 35434944
- Inhibition of Wdr5 Attenuates Ang-II-Induced Fibroblast-to-Myofibroblast Transition in Cardiac Fibrosis by Regulating Mdm2/P53/P21 Pathway. | Yuan, J., et al. 2022. Biomolecules. 12: PMID: 36358925
- WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma. | Mitchell, K., et al. 2023. Genes Dev. 37: 86-102. PMID: 36732025
- Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer. | Yu, X., et al. 2023. J Med Chem. 66: 16168-16186. PMID: 38019706
- METTL3 orchestrates glycolysis by stabilizing the c-Myc/WDR5 complex in triple-negative breast cancer. | Yuan, XN., et al. 2024. Biochim Biophys Acta Mol Cell Res. 1871: 119716. PMID: 38547933
- PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis. | Qin, Y., et al. 2024. Cancer Lett. 593: 216952. PMID: 38750719
- MBD2 regulates the progression and chemoresistance of cholangiocarcinoma through interaction with WDR5. | Wang, D., et al. 2024. J Exp Clin Cancer Res. 43: 272. PMID: 39350229
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR5 Antibody (SF-14) | sc-100895 | 100 µg/ml | $339.00 |