WDR5 Antibody (A-6): sc-393116
- WDR5 Antibody (A-6) is a mouse monoclonal IgM κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-35 mapping at the N-terminus of WDR5 of human origin
- recommended for detection of WDR5 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for WDR5 Antibody (A-6). This work is in progress.
WDR5 Antibody (A-6) is a mouse monoclonal IgM antibody that detects WDR5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). WDR5, also known as BMP-2-induced gene 3 kb or BIG-3, is a crucial component of the Trithorax (TRX) histone methyltransferase complexes, which are essential for regulating gene expression during vertebrate development. WDR5 plays a significant role in the activation of Hox genes and is involved in the global trimethylation of histone H3 at lysine 4 (H3K4me3), a modification that is vital for maintaining active transcriptional states. WDR5 presence in osteoblasts, chondrocytes, osteocytes, and marrow stromal cells highlights its importance in bone development and differentiation. Notably, WDR5 structure includes seven WD-repeats, which facilitate interaction with other proteins and enhance function in promoting osteoblast differentiation. WDR5 binding specifically to dimethylated Lys4 (K4me2) in histone H3 underscores its role in epigenetic regulation, making WDR5 a key player in developmental processes and a valuable target for research in gene regulation and differentiation pathways.
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WDR5 Antibody (A-6) References:
- MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. | Wu, M. and Shu, HB. 2011. Chin J Cancer. 30: 240-6. PMID: 21439245
- WDR5 high expression and its effect on tumorigenesis in leukemia. | Ge, Z., et al. 2016. Oncotarget. 7: 37740-37754. PMID: 27192115
- WDR5 Facilitates Human Cytomegalovirus Replication by Promoting Capsid Nuclear Egress. | Yang, B., et al. 2018. J Virol. 92: PMID: 29437978
- WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage. | Neilsen, BK., et al. 2018. BMC Cancer. 18: 673. PMID: 29925347
- WDR5 is a conserved regulator of protein synthesis gene expression. | Bryan, AF., et al. 2020. Nucleic Acids Res. 48: 2924-2941. PMID: 31996893
- WDR5 promotes the tumorigenesis of oral squamous cell carcinoma via CARM1/β-catenin axis. | Lyu, XY., et al. 2022. Odontology. 110: 138-147. PMID: 34398317
- WIN site inhibition disrupts a subset of WDR5 function. | Siladi, AJ., et al. 2022. Sci Rep. 12: 1848. PMID: 35115608
- Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. | Ding, J., et al. 2023. ACS Chem Biol. 18: 34-40. PMID: 36594833
- WDR5 is required for DUX4 expression and its pathological effects in FSHD muscular dystrophy. | Mocciaro, E., et al. 2023. Nucleic Acids Res. 51: 5144-5161. PMID: 37021550
- MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1. | Zhang, C., et al. 2023. Int J Oral Sci. 15: 48. PMID: 37852994
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
WDR5 Antibody (A-6) | sc-393116 | 200 µg/ml | $322.00 |