WDR33 Antibody (D-1): sc-374466

WDR33 Antibody (D-1) is a mouse monoclonal IgM antibody that detects WDR33 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR33 antibody (D-1) is available as the non-conjugated form. WDR33, also known as WD repeat domain 33, is a 1,336 amino acid nuclear protein that plays a crucial role in DNA recombination and cytodifferentiation, making WDR33 essential for proper cellular function and development. WDR33 is characterized by a unique structure, which includes one collagen-like domain and seven WD repeats, allowing WDR33 to participate in various regulatory mechanisms such as chromatin assembly, cell cycle control, and RNA processing. The presence of WD repeats, which are conserved motifs that typically form a tertiary propeller structure, is significant as these motifs facilitate protein-protein interactions that are vital for cellular signaling and function. WDR33 is highly expressed in the testis and is encoded by a gene located on human chromosome 2, a region associated with several genetic diseases, including Harlequin ichthyosis and Alström syndrome. WDR33′s ability to interact with other proteins involved in these pathways underscores WDR33′s importance in maintaining cellular homeostasis and highlights WDR33′s potential as a target for therapeutic interventions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

WDR33 Antibody (D-1) References:

1. Alstrom syndrome: confirmation of linkage to chromosome 2p12-13 and phenotypic heterogeneity in three affected sibs.  |  Zumsteg, U., et al. 2000. J Med Genet. 37: E8. PMID: 10882760
2. A novel WD40 repeat protein, WDC146, highly expressed during spermatogenesis in a stage-specific manner.  |  Ito, S., et al. 2001. Biochem Biophys Res Commun. 280: 656-63. PMID: 11162572
3. An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus.  |  Shulenin, S., et al. 2001. Cytogenet Cell Genet. 92: 204-8. PMID: 11435688
4. Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome.  |  Hearn, T., et al. 2002. Nat Genet. 31: 79-83. PMID: 11941370
5. Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.  |  Kelsell, DP., et al. 2005. Am J Hum Genet. 76: 794-803. PMID: 15756637
6. Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.  |  Patel, SB., et al. 1998. J Clin Invest. 102: 1041-4. PMID: 9727073

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDR33 Antibody (D-1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-WDR33 Antibody (D-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDR33 Antibody (D-1) Specifications

Alternate Product Name: WDR33

Product Clone Name: D-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 15-41

Epitope Target: WDR33

Epitope Species: human

Product Reactivity/Detection: WDR33

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for WDR33 Antibody (D-1): P: Blocking Peptide