WDR20 Antibody (38K): sc-100900

WDR20 Antibody (38K) is a mouse monoclonal IgG1 kappa light chain antibody that detects WDR20 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-WDR20 antibody (38K) is available as the non-conjugated format. WDR20 protein, also known as WD-repeat-containing protein 20 or DMR, is a 569 amino acid protein characterized by the presence of five WD-repeats, which are structural motifs that typically form a tertiary propeller configuration. This unique structure facilitates WDR20′s involvement in various cellular processes, including chromatin assembly, cell cycle regulation, signal transduction, RNA processing, apoptosis, and vesicular trafficking. The presence of WD-repeats in WDR20 suggests a role in complex signaling networks within the cell, and the existence of two isoforms due to alternative splicing further highlights WDR20′s functional diversity. Anti-WDR20 antibody (38K) enables researchers to explore WDR20′s intricate roles in cellular mechanisms and potential implications in various biological contexts.

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WDR20 Antibody (38K) References:

1. The WD repeat: a common architecture for diverse functions.  |  Smith, TF., et al. 1999. Trends Biochem Sci. 24: 181-5. PMID: 10322433
2. WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.  |  Li, D. and Roberts, R. 2001. Cell Mol Life Sci. 58: 2085-97. PMID: 11814058
3. The WD-40 repeat.  |  van der Voorn, L. and Ploegh, HL. 1992. FEBS Lett. 307: 131-4. PMID: 1644165
4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.  |  Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
5. WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.  |  Kee, Y., et al. 2010. J Biol Chem. 285: 11252-7. PMID: 20147737
6. Characterization of WDR20: A new regulator of the ERAD machinery.  |  Ju, LG., et al. 2018. Biochim Biophys Acta Mol Cell Res. 1865: 970-980. PMID: 29655804
7. WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.  |  Olazabal-Herrero, A., et al. 2019. Eur J Cell Biol. 98: 12-26. PMID: 30466959
8. The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling.  |  Ng, VH., et al. 2023. Nat Commun. 14: 6173. PMID: 37798301
9. WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc.  |  Jiang, L., et al. 2024. Proc Natl Acad Sci U S A. 121: e2407904121. PMID: 39432777
10. The ancient regulatory-protein family of WD-repeat proteins.  |  Neer, EJ., et al. 1994. Nature. 371: 297-300. PMID: 8090199
11. Folding of proteins with WD-repeats: comparison of six members of the WD-repeat superfamily to the G protein beta subunit.  |  Garcia-Higuera, I., et al. 1996. Biochemistry. 35: 13985-94. PMID: 8909296
12. Folding a WD repeat propeller. Role of highly conserved aspartic acid residues in the G protein beta subunit and Sec13.  |  Garcia-Higuera, I., et al. 1998. J Biol Chem. 273: 9041-9. PMID: 9535892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-WDR20 Antibody (38K) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-WDR20 Antibody (38K) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

WDR20 Antibody (38K) Specifications

Alternate Product Name: WDR20

Product Clone Name: 38K

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-570

Epitope Target: WDR20

Epitope Species: human

Product Reactivity/Detection: WDR20

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for WDR20 Antibody (38K): N/A